It has been hypothesized that the observed excess risk of multiple myeloma (MM) among obese persons could be the result of altered circulating levels of adipokines, polypeptide hormones with pro- and anti-inflammatory properties secreted by adipose tissue. We investigated whether circulating levels of leptin, total adiponectin, and high molecular weight adiponectin are associated with subsequen...

Although obesity-related deficiency of adipokines is known to contribute increased psoriasis severity and decreased clinical response interventions, the mechanism by which it exacerbates poorly defined. We hypothesized that suppress activation innate immune responses in keratinocytes skin-resident Th17/γδ T cells. In preliminary studies, we confirmed diet-induced obese (DIO) mice had significan...

How hepatatitis C virus (HCV) infection affects the interplay among abundant adipokines in the host remains unclear. A prospective study was conducted with 450 consecutive genotype 1 (G1) and G2 HCV patients who completed a course of anti-HCV therapy and underwent pre-therapy and 24-week post-therapy surveys to assess various profiles and levels of abundant adipokines, including leptin, adipone...

OBJECTIVE To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and cardiometabolic risk factors. RESEARCH DESIGN AND METHODS Participants from the Framingham Heart Study offspring cohort (n = 916, 55% women; mean age 59 years) free of cardi...

We examined the association between adipokines (leptin, adiponectin, and resistin), radiotherapy, measurement of body fat, and insulin resistance among young adult survivors of childhood cancer (CCS). Materials and Methods. Seventy-six survivors were included (mean age 24.1 ± 3.5 years). Insulin resistance (IR) was calculated using the homeostasis model assessment (HOMA-IR). The serum levels of...

BACKGROUND/AIMS Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. METHODS A tot...

objective(s):non-alcoholic steatohepatitis (nash), is an important component of non-alcoholic fatty liver disease (nafld) spectrum, which progresses to the end stage liver disease, if not diagnosed and treated properly. the disproportionate production of pro- and anti-inflammatory adipokines secreted from fat contributes to the pathogenesis of nash. in this study, the comparative effect of piog...

Sood A. Obesity, adipokines, and lung disease. J Appl Physiol 108: 744–753, 2010. First published November 19, 2009; doi:10.1152/japplphysiol.00838.2009.— This review summarizes the state of the current literature relating to the associations of lung disease on obesity and adipokines (proteins produced by adipose tissue) in humans. Obesity is an independent risk factor for asthma. Recent studie...