Naive T cells are usually excluded from nonlymphoid tissues. Only when such tertiary tissues are subjected to chronic inflammation, such as in some (but not all) autoimmune diseases, are naive T cells recruited to these sites. We show that the CCR7 ligand CC chemokine ligand (CCL)21 is sufficient for attracting naive T cells into tertiary organs. We performed intravital microscopy of cremaster ...

Central memory CD8(+) T cells (T(CM)) confer superior protective immunity against infections compared with other T cell subsets. T(CM) recirculate mainly through secondary lymphoid organs, including peripheral lymph nodes (PLNs). Here, we report that T(CM), unlike naive T cells, can home to PLNs in both a CCR7-dependent and -independent manner. Homing experiments in paucity of lymph node T cell...

The dissociative chemisorption of CH4 on Pt(111) was studied using quantum state-resolved methods at a surface temperature (T(s)) of 150 K where the nascent reaction products CH3(ads) and H(ads) are stable and accumulate on the surface. Most previous experimental studies of methane chemisorption on transition metal surfaces report only the initial sticking coefficients S0 on a clean surface. Re...

The close-grip bench press (CGBP) is a variation of the traditional bench press (TBP) that uses a narrower grip (~95% of biacromial distance (BAD)) and has potential application for athletes performing explosive arm actions from positions where the hands are held close to the torso. Limited research has investigated CGBP mechanics compared to the TBP. Twenty-seven resistance-trained individuals...

Mathematical model for a pilot scale iron ore pellet induration furnace has been developed which considers the process of induration including the reactions of limestone, magnetite and coke. The differential equations of energy, mass and momentum are solved simultaneously. The profiles of temperature, pressure and concentration are obtained. Performing separate experiments on sub processes; dry...

Laboratory experiments revealed that CO$_{2}$ ice particles stick less efficiently than H$_{2}$O particles, and there is an order of magnitude difference in the threshold velocity for sticking. However, surface energies elastic moduli ices are comparable, reason why were poorly sticky compared to was unclear. Here we investigate effects viscoelastic dissipation on sticking using contact model d...

Scholars studying human organizations have recently adopted the notion of fitness landscapes, a concept pioneered in the biological and physical sciences. Such scholars have generally assumed that organizations will migrate toward the local peaks of these landscapes, as biological and physical entities do. We use an agentbased simulation to show, to the contrary, that a hierarchical human organ...

When identical dots moving at equal velocities but in opposite directions become coincident, a striking illusion occurs. The dots appear to pause momentarily, despite no objective change in velocity. Three models for the illusion were examined: A vector averaging model best accounts for the data. According to this model a motion system maps visual space and assigns motion vectors to each positi...

f patience is a virtue, then Daniel Goodenough and Bruce Stevenson earned their wings in the pursuit of the first tight junction protein. Stevenson spent seven years as a graduate student with Goodenough (Harvard Medical School, Boston, MA) before the two worked out the conditions to purify fragile tight junction–enriched preparations from mouse liver (Stevenson and Goodenough, 1984). It was en...