Purpose: There are no effective therapies for patients with poorly differentiated papillary thyroid cancer (PTC) or anaplastic thyroid cancer (ATC), and metastasis to the bone represents a significantly worse prognosis. Src family kinases (SFKs) are overexpressed and activated in numerous tumor types and have emerged as a promising therapeutic target, especially in relation to metastasis. We re...

Thyroid cancer is one of the most common malignancies of endocrine organs, and its incidence rate has increased steadily over the past several decades. Most differentiated thyroid tumors derived from thyroid epithelial cells exhibit slow-growing cancers, and patients with these tumors can achieve a good prognosis with surgical removal and radioiodine treatment. However, a small proportion of pa...

It is also known that RAI treatment can induce an alteration in immune response to thyroid antigens in Graves’ disease (5). Thus it is also possible that thyroid antigens can be released into the circulation after destruction of thyroid cells by RAI in patients with thyroid cancer. Evidence for this comes from our previous study which showed that serum thyroid peroxidase was detectable after RA...

background: thyroid carcinoma is the most common malignancy of the endocrine system. papillary thyroid carcinoma (ptc) is the most common type of thyroid cancer, accounting for 70–90% of well-differentiated thyroid malignancies. thyroid papillary microcarcinoma is a subtype of papillary carcinoma that included tumors with less than 10mm diameter. as a result of diagnostic methods improvement, p...

UNLABELLED Follow-up diagnostic radioiodine whole-body scintigraphy (DxWBS) is still advised for high-risk patients with differentiated thyroid cancer. The aim of this study was to evaluate the additional value of DxWBS to stimulated thyroglobulin measurement in high-risk patients. METHODS The results of DxWBS and thyroglobulin measurements performed 6-12 mo after surgery and radioiodine thyr...

The tumour suppressor gene PTEN/MMAC1/TEP1 has been implicated in a variety of human cancers and several inherited hamartoma tumour syndromes, including Cowden syndrome, which has a high risk of breast and thyroid cancer. We have previously reported that overexpression of PTEN in MCF-7 breast cancer cells induces cell cycle arrest and apoptosis. In this study, we analysed PTEN status at both th...

Background. Use of radioactive iodine (RAI) ablation has been reported to vary significantly between studies. We explored variation in RAI ablation care patterns between seven thyroid cancer treatment centers in Canada. Methods. The Canadian Collaborative Network for Cancer of the Thyroid (CANNECT) is a collaborative registry to describe and analyze patterns of care for thyroid cancer. We analy...

The term thyroid neoplasm incorporates tumors that originate from follicular cells and those arise parafollicular (C cells). Differentiated cancer, which originates cells, includes papillary carcinoma (PTC), (FTC), oncocytic cell (Hürthle), poorly differentiated carcinoma, anaplastic (ATC). PTC tends to have an indolent clinical course with low morbidity mortality. However, this entity has a br...