Hair cell loss is a major cause of sensorineural hearing loss. We have developed a method to examine metabolic events in hair cells in response to stimuli known to cause hair cell loss, such as acoustic trauma and aminoglycoside administration. The method employs two-photon excitation of the metabolic intermediate, reduced nicotinamide adenine dinucleotide (NADH), in hair cell mitochondria in a...

Background: Female-pattern hair loss (FPHL) is a common form of in women and referred to as androgenetic alopecia. It characterized by diffuse reduction density on the crown frontal scalp with retention hairline. Objective: This study aimed examine trichoscopic findings FPHL correlate their relationship disease severity our tertiary care hospital. Materials Methods: was prospective, observation...

The role of mitochondrial biogenesis in hair cell survival after injury was evaluated by inhibiting mitochondrial protein synthesis with chloramphenicol and then studying the effects on hair cell survival after exposure to two different types of ototoxins, gentamicin and acoustic trauma. Seven- to 10-day-old chicks were treated with either a single injection of gentamicin (250 mg/kg) or noise (...

Alopecia areata is a chronic relapsing autoimmune disease characterized by local or diffuse non-scarring hair loss. Statistically, 0.2% of people worldwide are affected alopecia and 1.7% were diagnosed with it at some point in life. The incidence children has been rapidly increasing recent years.
 main role pathogenesis belongs to the loss immune privilege due influence genetics various ex...

Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss diso...

plays an important role in the etiology of postoperative transient hair loss. Its general presentation in the occipital area supports the pressure effect. Hair loss begins between postoperative day 3 and 28. Normal hair structure is expected to be acquired within 120 days. Physiological disorders were reported to trigger postoperative tranFig. 5. Appearance of transient hair loss at postoperati...

The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of the synaptic connections b...

The innervation of the inner ear critically depends on the two neurotrophins Ntf3 and Bdnf. In contrast to this molecularly well-established dependency, evidence regarding the need of innervation for long-term maintenance of inner ear hair cells is inconclusive, due to experimental variability. Mutant mice that lack both neurotrophins could shed light on the long-term consequences of innervatio...

We have used time-lapse imaging to study cisplatin-induced hair cell death in lateral line neuromasts of zebrafish larvae in vivo. We found that cisplatin-induced hair cell death occurred much more slowly than had been shown to occur in aminoglycoside-induced hair cell death. By prelabeling hair cells with FM1-43FX, and assessing hair cell damage, it was established that cisplatin causes hair c...