Pyridazine plays a significant role in pharmaceuticals particularly in the field of medicinal chemistry. Several 4-substituted-benzylidene-6-substituted-phenyl-dihydro-pyridazin-3(2H)-one derivatives (3a-q) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antitubercular agents. In the first step, 6-aryl-tetrahydro-pyridazin-3-ones (2) were prepar...

In the present study, the synthesis of diethylene triamine supported on cellulose biopolymer as a biodegradable solid basic heterogeneous catalyst was suggested. Then, the applicability of the synthesized catalyst cellulose bonded N-propyl diethylene triamine (CBPDETA) was tested for the synthesis of oxindole derivatives, an important class of potentially bioactive compounds. A various series o...

A number of alkyl and acyl derivatives of 4-dihydro-4-deoxy-4(R)-amino spectinomycin were tested against various Escherichia coli strains, possessing different susceptibilities to spectinomycin. The influence of the lipophilicity and the length of the side chain substituents of the derivatives was compared to both minimal inhibitory concentration values and stability to adenyltransferase. Deriv...

In the present investigation, some new pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives (7-12) as well as fused pyrazolo[3',4':4,5]pyrimido[1,2-b]pyridazin-4(1H)-one (14-16) and 7,8,9,10-tetrahydropyrazolo[3',4':4,5]pyrimido[1,2-b]-cinnolin-4(1H)-one (17) ring systems were synthesized using the starting compound 5-amino-6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (5). The stru...