BACKGROUND The aim of this study was to determine the relationship between the morphological and physiological information of coronary CT angiography (CCTA) and stress myocardial perfusion imaging (S-MPI) from the standpoint of risk stratification of patients with intermediate to high probability of coronary artery disease (CAD). METHODS AND RESULTS In total, 51 patients underwent both CCTA a...

w Myocardial perfusion imaging (MPI) in acute myocardial infarction (MI) has had its ups and downs over the past 4 decades (1). “Cold-spot” imaging with thallium-201, technetium-99m tetrofosmin and sestamibi, wall motion assessment with gated radionuclide angiography, and “hot-spot” imaging with radionuclide-bound pyrophosphate, glucarate, antimyosin, annexin V (2), and more recently, duramycin...

Myocardial dysfunction, perfusion abnormalities, and the extent to which these abnormalities may be reversed by C-peptide administration was assessed in type 1 diabetic patients. Eight patients were studied before and during a 0.84-mg/kg dipyridamole administration using a randomized double-blind crossover protocol with infusion of C-peptide (6 pmol x kg(-1) x min(-1)) or saline during 60 min o...

Over the past 20 years, SPECT myocardial perfusion imaging (MPI) has become an important tool for assessing patients with known or suspected coronary artery disease (CAD). Despite the success of SPECT MPI, laboratories that are performing these procedures are under pressure to reduce costs, improve image acquisition efficiency, reduce absorbed radiation dose, and improve diagnostic accuracy. Ph...

Background We previously introduced a model-based approach (Decisions Informed by Computed Entities [DICE]), a mathematical form of Artificial Intelligence (AI) to improve prognostic values of quantitative myocardial perfusion imaging (MPI). When DICE was applied to cardiovascular MRI (CMR) it improved prediction of MACE in women with suspected ischemic heart disease (IHD) compared to the conve...

Received 2/12/2007; revised 3/16/2007; accepted 3/16/2007. For correspondence or reprints contact: Guang-Uei Hung, M.D., Department of Nuclear Medicine, Changhua Christian Hospital. 135 Nan-Shiao Street, Changhua 500, Taiwan. Tel: (886)4-7238595 ext. 3091, E-mail: [email protected] Background: Gated myocardial perfusion SPECT simultaneously evaluates myocardial perfusion at tracer injection and...

  Objective: IQSPECT is an advanced high-speed SPECT modality for performing myocardial perfusion imaging (MPI), which uses a multi-focus fan beam collimator with resolution recovery reconstruction. The aim of this study was to compare IQSPECT compared with conventional SPECT interms of performance based on standard clinical protocols. In addition, we examined the concordance between convention...

The use of cardiac imaging modalities has grown steadily, and cardiac nuclear studies constitute a large part of this number. Nuclear Cardiology is often mistakenly considered a synonym of myocardial perfusion imaging (MPI), but has broader applications, including metabolic imaging, innervation imaging, among other technologies. MPI has been a powerful diagnostic and prognostic tool in the asse...

Purpose Historically, assessments of myocardial perfusion have relied heavily on measurements of myocardial blood flow (MBF). However, because only ~50% of capillaries are functional at rest [1], the recruitment of capillaries, or changes in myocardial blood volume (MBV), may also play a significant role in supplying O2 to the myocardium [2]. Our MRI methods can quantify MBF, MBV, oxygen extrac...

objective: the risk of cardiac death in diabetic patients is 3 times more than non-diabetics. but it is not determined who need cardiac screening. about 41% of diabetic patients with silent ischemia are missed. the carotid intima-media thickness (cimt) and ankel brachial index are two independent,simple and non invasive method in vascular complications diagnosis in diabetic patients.the aim of ...