MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metab...

The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G prot...

Causal discovery is the task of finding plausible causal relationships from statistical data. Such methods rely on various assumptions about the data generating process to identify it from uncontrolled observations. We have recently proposed a causal discovery method based on independent component analysis (ICA) called LiNGAM, showing how to completely identify the data generating process under...

This paper proposed a robot reinforcement learning method based on learning classifier system. A Learning Classifier System is a accuracy-based machine learning system with gradient descent that combines reinforcement learning and rule discovery system. The genetic algorithm and the covering operator act as innovation discovery components which are responsible for discovering new better reinfor...

AbstRAct Organizations are beginning to apply data mining and knowledge discovery techniques to their corporate data sets, thereby enabling the identification of trends and the discovery of inductive knowledge. Many times, traditional transactional databases are not optimized for analytical processing and must be transformed. This article proposes the use of modular components to decrease the o...

Service discovery is an important and necessary component of ad hoc networks. To fit within the context of such networks, a post-query model with several service discovery strategies (named post-query strategies) are proposed, with a focus on locating services. Strategies consists of a sequence of post-query protocols executed in rounds and based on the location method employed they include the...

In this paper we present a scalable, distributed architecture that allocates idle CPUs for task execution, where any node may request the execution of a group of tasks by other ones. A fast, scalable discovery protocol is an essential component. Also, up to date information about free nodes is efficiently managed in each node by an availability protocol. Both protocols exploit a tree-based peer...

The introduction of software development via Web Services has been the most significant web engineering paradigm, in the last years. The widely acknowledged importance of the Web Services’ concept lies in the fact that they provide a platform independent answer to the software component development question. Equally important are the mechanisms that allow for Web Service discovery, especially a...

The device discovery time of Bluetooth is prohibitively long. This may significantly impact many mobile applications. In this work, we start by analyzing the frequency matching of Bluetooth, the major component of delay in its device discovery, for both versions V1.2 and V1.1 specifications. We then propose a new scheme called Dual Inquiry Scan to reduce the delay. The result is a reduction of ...

The Discovery Channel Telescope (DCT) is a 4.3-meter astronomical research telescope being built in northern Arizona as a partnership between Discovery Communications and Lowell Observatory. The project software team has designed and partially implemented a component-based system. We describe here the key features of that design (state-based components that respond to signals) and detail specif...