Developing game is anymore essentially a personal effort. The game development process is an important issue. In fact, games are becoming more and more complex task, involving multidisciplinary teams composed by member with specialised knowledge and skills. In this paper, we propose a framework, based in the information systems development literature and aplied to game development. This framewo...

Varicocele is characterized by abnormal tortuosity and dilation of the veins of the pampiniform plexus within the spermatic cord. Although several reports show the mechanisms by which the varicocele exerts its infertility impact, the exact pathophysiology for varicocele-induced inflammation and its relationship with testicular endocrine disruption remain largely unknown. This review article wil...