a number of patients with inflammatory arthritis due to inadequate clinical or laboratory data do not fulfill diagnostic criteria for a clinical disease categories. these patients with initial diagnosis of undifferentiated arthritis (ua) may remit or progress to a definite well- defined condition such as rheumatoid arthritis (ra) or remain as ua with persistence of inflammatory arthritis. the m...

Interstitial lung disease involves all areas of medicine as it often occurs in patients with comorbidities or as a consequence of systemic diseases and their treatment. Typically the physician is faced with a breathless patient, a diffusely abnormal chest radiograph, and a wide differential diagnosis. Progress has been made in using high resolution computed tomography as the key investigation i...

SEVERAL DISCOVERIES IN THE FIELD OF PROSTAGLANDINS have added substantially to our knowledge of platelet-vessel wall interactions and opened up exciting new therapeutic possibilities. This review will discuss mainly the way in which some of these compounds interact to regulate platelet aggregability in physiological and pathological conditions. The biological properties of prostacyclin and the ...

Each of the basic operative methods for Hirschsprung's disease (the rectosigmoidectomy developed by Swenson, the retrorectal transanal approach developed by Duhamel, and the endorectal procedure developed by Soave and modified by Denda and Boley) can give good results. A protective colostomy should be routine. If only an occasional case is prevented from progressing to incontinence or septicemi...

During the onset of Moyamoya disease (MMD), progressive occlusion occurs at the end of the intracranial internal carotid artery, and compensatory net-like abnormal vessels develop in the skull base, generating the corresponding clinical symptoms. MMD can affect both children and adults, but MMD in pediatric patients exhibits distinct clinical features, and the treatment prognoses are different ...

sarcopenia and physical inactivity synergistically progress in patients with chronic kidney disease (ckd) and are strong predictors of mortality in this population. exercise training and essential amino acids and vitamin d supplements may contribute to improving sarcopenia and physical inactivity in ckd patients.

The progress in defining the immunological and inflammatory mechanisms that lead to the progressive joint destruction in rheumatoid arthritis (RA) [1,2] has led to the development of new inhibitory drugs. Large randomized controlled trials have shown the efficacy of the new treatments and led to the recent approval of several new drugs by American and European health authorities. These are the ...