An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel re...

We study an underdamped oscillator with random frequency jumps. We describe the oscillator spectrum in terms of coupled susceptibilities for different-frequency states. Depending on the parameters, the spectrum has a fine structure or displays a single asymmetric peak. For nanomechanical resonators with a fluctuating number of attached molecules, it is found in a simple analytical form. The res...

A urea broth microdilution method to assay the susceptibilities of seven Malassezia species was developed. This method indicated the same sensitivities as the agar plate dilution method for isolates of Malassezia furfur, M. pachydermatis, M. slooffiae, and M. sympodialis.

It seems common knowledge that school sport participation leads to all kinds of social, educational and health outcomes. However, it may also be that students with a certain predisposition, sometimes referred to as sporting habitus, are more inclined to participate in school sports and that the 'outcomes' were already present before participation. Several studies indicated that identity formati...

For more than a decade, biometric moderation models have been used to examine whether genetic and environmental influences on individual differences might vary within the population. These quantitative Gene × Environment interaction models have the potential to elucidate not only when genetic and environmental influences on a phenotype might differ, but also why, as they provide an empirical te...

A broth dilution assay was used to determine the in vitro susceptibilities of 10 ocular isolates of Bacillus cereus to clindamycin, gentamicin, and vancomycin both alone and in combination. The checkerboard technique was used to determine fractional inhibitory and bactericidal concentration indices for combinations of clindamycin-gentamicin and vancomycin-gentamicin.

Determining how individuals adjust their behaviour to maximize reproductive opportunities is fundamental to understanding the adaptive significance of behavioural variations. Such 'decision making' requires recognition mechanisms, whereby an individual evaluates cues that yield information about the potential reproductive outcomes of alternative behaviours. Here, we develop a quantitative model...

Six patients with Acinetobacter genomic species 10 bacteremia were identified. The clinical features of the patients, phenotypic and genotypic identifications, antimicrobial susceptibilities, and genes flanking ISAba1 of the bacteria were described. The results revealed that this bacterium is a potentially lethal pathogen that can cause health care-associated infections in debilitated patients.

The susceptibilities of 63 isolates of Aspergillus spp. to voriconazole were evaluated by a modified NCCLS M38-A method and the Sensititre YeastOne method. The overall agreement was 82.5%, ranging from 100% for Aspergillus niger and Aspergillus terreus to 62.5% for Aspergillus flavus. Discrepancies between the methods were due to higher Sensititre MICs. The Sensititre YeastOne method could have...

The "default system" of the brain has been described as a set of regions which are 'activated' during rest and 'deactivated' during cognitively effortful tasks. To investigate the reliability of task-related deactivations, we performed a meta-analysis across 12 fMRI studies. Our results replicate previous findings by implicating medial frontal and parietal brain regions as part of the "default ...