The interferons (IFNs) are glycoproteins which have, in addition to anti-viral activity, antiproliferative and immunomodulating properties (Borden, 1979; Billiau, 1981). The latter two suggested an anti-tumour potential for these substances and IFN has now been used in the treatment of a variety of malignant diseases. To date, there have been no reports of its use in human hepatocellular carcin...