Laminin-binding integrins (α3β1, α6β1, α6β4, α7β1) are almost always expressed together with tetraspanin CD151. In every coexpressing cell analyzed to date, CD151 makes a fundamental contribution to integrin-dependent motility, invasion, morphology, adhesion and/or signaling. However, there has been minimal mechanistic insight into how CD151 affects integrin functions. In MDA-MB-231 mammary cel...

To evaluate the metabolic adaptations of the brain to acute respiratory acid-base disturbances, a method was developed to measure intracellular pH (pHi) in the brain of dogs under conditions in which arterial pH is rapidly altered. Brain pHi was determined by measuring the distribution of 14C-labeled dimethadione (DMO) in brain relative to cortical CSF. Brain extracellular space (ECS) was evalu...

Multimedia plays a role on the Web which is guaranteed to grow in significance as individuals and organizations increasingly generate digital content. Parallel to the development of richer media online is the discovery of “Web as platform”, termed Web 2.0 in some quarters.. As rich media and Web 2.0 converge, new requirements arise which need new solutions. In this paper, we describe the SOCITU...

1. Whole-body intracellular pH (pHi) was measured by the 14C-labelled DMO method in twenty-four control subjects, eighteen normal subjects with induced acute metabolic alkalosis, ten normal subjects with induced acute metabolic acidosis, twelve normal subjects with chronic acidosis and in fifteen patients with chronic renal insufficiency and acidosis. 2. The change in pHi per unit change in ext...

We identified the single gene for nuclear lamin in the genome draft of the sea anemone Nematostella vectensis, a member of the cnidaria, a very old metazoan phylum. The gene consists of 10 exons and 9 introns. Strikingly all 9 intron positions are conserved in the human lamin B genes, which have only 1 (lamin B1) or 2 (lamin B2) additional introns. Using the information on neighboring genes we ...

The present research was carried out in the sample of Salda Lake Turkey order to determine perception local residents about cultural, economic and environmental effects ecotourism identify effect these variables on their support for tourism development region. In research, it concluded that act as an antecedent by people residing around addition, people’s length residence region creates a moder...

[1] Isotopic analyses of dissolved molybdenum are presented for sediment pore waters from a reducing sedimentary basin and for fluids from a low-temperature ridge flank hydrothermal system. dMo in these fluids range from 0.8 to 3.5% (relative to a laboratory standard), demonstrating that marine sedimentary reactions significantly fractionate Mo isotopes. Within the upper 3 cm of sediment, manga...

Decision-making (DM) knowledge is often represented as a set of basic definitions such as alternatives, criteria, decision matrix, and decision itself. However, this domain is much richer, and many other related notions are useful to make right decisions: preferences, weights, thresholds, and so on. This knowledge must be formalized within a model. In addition, the practical needs for DM as wel...

Myocardial intracellular pH was measured in a perfused rainbow trout, Salmo gairdneri, with DMO (5,5-dimethyl-2,4-oxazlidinedione), to test the hypothesis that catecholamines promote active regulation of myocardial pH in order to protect contractility during a respiratory acidosis comparable to that observed after exercise. Under control conditions (extracellular pH = 8.0; PCO2 = 2 Torr), myoca...