نتایج جستجو برای: dn
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I. THE SETUP At time t, let V (t) be the event {the DN is empty at time t}. If V̄ (t), let C∗(t) be the oldest customer in the DN, let W∗(t) be the time C∗(t) has spent in the DN, and let I∗(t) be the queue in the DN which C∗(t) goes through. For n ≥ 0, let E(t, s, n) = {at least n customers arrived at the DN on the interval (t− s, t], out of which at least n have left the DN by t}. Let the size...
Diabetic nephropathy (DN) is a chronic complication of diabetes and the most common cause of end-stage kidney disease. It has been reported that multiple factors are involved in the pathogenesis of DN, while the molecular mechanisms that lead to DN are still not fully understood. Numerous risk factors for the development of diabetic nephropathy have been proposed, including ethnicity and inheri...
BACKGROUND The development and validation of Norfolk QOL-DN, a fiber-specific, quality-of-life tool for diabetic neuropathy, was published previously (Part 1). This study (Part 2) defines the psychometric properties of the German-translated Norfolk QOL-DN in a large multicenter (96 sites) population with neuropathy ranging from minimal to severe, comparing them with those in the original Englis...
Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality of life, DN accounts for a large proportion of the excess mortality associated with type 1 diabetes (T1D). Whereas the degree of glycemia plays a p...
Diabetic nephropathy (DN) is a kidney disorder secondary to diabetes and one of the main diabetic microvascular complications. As number patients grows, DN has become leading cause chronic disease in China. Unfortunately, no definitive cure currently exists for DN. Cornus officinalis (CO), frequently utilized clinical settings mellitus treatment, proven vital both preventing treating This artic...
CONTEXT Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. EVIDENCE ACQUISITIONS Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. RESULTS...
[1] We measured dN signatures of macrophytes and particulate organic matter (POM) in six estuaries and three freshwater ponds of Massachusetts to assess whether the signatures could be used as indicators of the magnitude of land-derived nitrogen loads, concentration of dissolved inorganic nitrogen in the water column, and percentage of N loads contributed by wastewater disposal. The study focus...
PPARgamma ligands have been shown to have antiproliferative effects on many cell types. We herein report that a synthetic dominant-negative (DN) PPARgamma mutant functions like a growth factor to promote cell cycle progression and cell proliferation in human coronary artery smooth muscle cells (CASMCs). In quiescent CASMCs, adenovirus-expressed DN-PPARgamma promoted G1-->S cell cycle progressio...
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. DN typically manifests by glomerular hyperfiltration and microalbuminuria; then, the disease progresses to impaired glomerular filtration rate, which leads to ESRD. Treatment options for DN include the strict control of blood glucose levels and pressure (e.g., intraglomerular hypertension). However, the ...
Apoptosis signal-regulating kinase-1 (ASK-1) is an important molecule for the pro-apoptotic signaling. ASK-1 also contributes to the cellular survival for many types of cells. Thus, ASK-1 has a broad range of biological activities depending on the cell type. The present study assessed the role(s) of ASK-1 in colorectal cancer cells (HT-29) by using adenovirus vectors expressing wild-type (WT)-A...
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