Background: It is stated that pentoxifyline can improve sperm motility and suggested to use in ART for asthenozoospermia. But, probable effect of this drug on sperm DNA in unknown. Our main goal was to evaluate the impact of pentoxifyline on sperm DNA fragmentation. Materials and Methods: Thirty eight asthenozoospermic patients were selected for this prospective study. After direct swim-up, spe...

The assessment of the indicators reproductive potential male white rats exposed to smoke for 1 month was carried out. Examination animals included determination spermatogenesis index and level DNA fragmentation methylation in testes blood. A statistically signifi-cant increase genome-wide blood revealed. morphometric study testis tissue revealed a violation indices rats.

We evaluated the effect of varicocelectomy on semen parameters and levels of sperm DNA damage in infertile men. A total of 75 infertile men with varicocele and 40 fertile men (controls) were included in this study. Semen analysis and sperm DNA damage expressed as the DNA fragmentation index using acridine orange staining and chromatin condensation test by flow cytometry were assessed before and...

Diagnosis of sperm DNA integrity of semen sample is important for consistently high reproductive efficiency. The conventional parameters of semen analysis take into account morphology, motility, and concentration of spermatozoa in the sample, which are insufficient for evaluation of reproductive potential. Current studies have implicated abnormal organization of genomic material in sperms as a ...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Drs. Fraczek and Kurpisz, in their insightful commentary, highlighted the pitfalls of the current sperm DNA fragmentation (SDF) testing (1). These authors remarked that the association between SDF and clinical outcome of assisted reproduction is not without controversy in the literature. An interesting study cited by ...

OBJECTIVE To evaluate the effect of vaginal lubricants Pre-Seed, FemGlide, Astroglide, and Replens on human sperm motility and chromatin integrity. DESIGN Prospective, comparative, in vitro study. SETTING Andrology laboratory at tertiary care hospital. PATIENT(S) Thirteen normozoospermic donors. INTERVENTION(S) Semen samples from 13 subjects were incubated in human tubal fluid media (HT...

The displacement- and frequency-noise-free interferometer (DFI) is a multiple laser interferometer array for gravitational-wave detection free from both the displacement noise of optics and laser frequency noise. So far, partial experimental demonstrations of the DFI have been done in 2D table top experiments. In this Letter, we report the complete demonstration of a 3D DFI. The DFI consists of...

Background: Although sperm selection according to morphologic and motility characteristic, made to some what the fertility successful, but sperm’s normal morphology cannot demonstrate sperm DNA competence. Since the health of sperm DNA is affecting the results of assisted reproductive technology; the aim of this study is to evaluate semen parameters measured by CASA with sperm chromatin abnorma...