microbial risks associated with food, water, and wastewater use in agriculture (e.g., [1, 3, 5]). The core part of the QMRA framework is the dose-response analysis which models the mathematical characterization of the relationship between the dose administered and the probability of adverse effect (typically, the probability of infection) in the exposed population [1, 2, 6]. Among different mic...

Angiotensin II (Ang II) is known to enhance the vasoconstrictor response to norepinephrine (NE). In the present study, this interaction was investigated using isolated rabbit femoral artery rings mounted in tissue baths for the measurement of isometric contraction. Exposure to 3 x 10(-10) M Ang II caused a contraction that was less than 5% of the maximal response to NE. In the presence of Ang I...

Angiotensin II (Ang II) is known to enhance the vasoconstrictor response to norepinephrine (NE). In the present study, this interaction was Investigated using isolated rabbit femoral artery rings mounted in tissue baths for the measurement of isometric contraction. Exposure to 3 x 10~ M Ang II caused a contraction that was less than 5% of the maximal response to NE. In the presence of Ang II, t...

putative activity of hydroalcoholic and aqueous infusion extracts of echium amoenum l. was investigated in mice using the rotarod model of motor coordination and the elevated plus maze model of anxiety. the extracts were administered intraperitonealy (i.p.) once, one hour before performing the tests. preliminary phytochemical study of the plant, with standard procedures, showed that it contains...

We describe a data reduction procedure to assign statistically accurate estimates of unknown hormone concentrations, with associated uncertainties, based on experimental uncertainties in sample replicates and the fitted calibration curve. Three mathematical calibration curve functions are considered. The one providing optimal statistical characterization of reference calibrators is chosen for u...

The effect of hyperglycemia on the cytotoxic effect of a chemotherapeutic agent was studied at elevated temperature. The seventh generation of a spontaneous C3Hf/Sed mouse fibrosarcoma, FSa-II, was transplanted into the footpads of the same strain of mice. Hyperthermia was given by immersing animal feet into a water bath where 41.5 +/- 0.1 degrees (range) was maintained by a constant temperatur...

PURPOSE ATN-161 (Ac-PHSCN-NH(2)) is an integrin-binding peptide that is currently in phase II trials in cancer patients. This peptide has been shown to have antitumor activity in a number of different preclinical models. EXPERIMENTAL DESIGN In this study, we examined the binding, biodistribution, and dose and biomarker response of ATN-161 in several animal models. RESULTS ATN-161 bound to t...