Both Pfizer and Moderna vaccine trials used accelerated methods to achieve rapid FDA approval with minimal wise compromises. While many established vaccines use boost / dose 2 timings that are typically in the 3 120 months range , for both were less than 30 days as part of a crucial effort rapidly develop significant efficacy. Data from showed excellent 1 efficacy; however, neither related Safe...

India witnessed a devastating second surge of COVID-19 cases from March 2021. Evidence strongly advocates its association with the patients’ age, gender, pre-existing comorbidity, vaccination status, and Remdesivir administration during treatment disease. The objective this study is to evaluate significant relation these five factors in-hospital mortalities. We conducted retrospective, cross-se...

Routine immunization is recommended for adolescents aged 11-12 years by the Advisory Committee on Immunization Practices (ACIP) for protection against diseases including pertussis, meningococcal disease, and human papillomavirus (HPV)-associated cancers. To assess vaccination coverage among adolescents, CDC analyzed data collected regarding 20,827 adolescents through the 2014 National Immunizat...

conclusions epo resistance was negatively associated with anti-hbs levels and seroconversion. more studies are needed to highlight the underlying mechanisms regarding epo resistance and response to hbv vaccination in hd patients. results in total 97 patients were enrolled. for the entire group, stepwise linear regression analysis revealed that square root transformed anti-hbs levels were indepe...

BACKGROUND Previous studies from Africa have suggested that there is little benefit to be gained from early two-dose measles vaccination schedules. Two-dose schedules have been associated with no improvement in coverage due to immunization of the same individuals on both occasions, low return rate, high refusal rate, low vaccine efficacy, and fear of blunting of the antibody response. Because o...

BACKGROUND A two-dose preoperative vaccination schedule against HBV has been the widely accepted policy in Poland. However, its effectiveness has not yet been assessed. OBJECTIVE To evaluate a two-dose preoperative HBV vaccination policy by an assessment of the proportion of patients who don't present a protective level of anti-HBs (<10.0 mIU/ml). METHODS Consecutive patients from surgical/...

BACKGROUND Acellular pertussis vaccines do not control pertussis. A new approach to offer protection to infants is necessary. BPZE1, a genetically modified Bordetella pertussis strain, was developed as a live attenuated nasal pertussis vaccine by genetically eliminating or detoxifying 3 toxins. METHODS We performed a double-blind, placebo-controlled, dose-escalating study of BPZE1 given intra...

Abstract Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment this phenomena is warranted for vaccine SARS CoV-2. Here we report detailed immune profiling ChAdOx1 nCoV-19 (AZD1222) and subsequent high dose challenge two animal models mediated disease. We demonstrate rhesus macaques the ...

OBJECTIVE To estimate the benefits, cost-effectiveness (i.e., value for money), and required financial costs (e.g., affordability) of adding human papillomavirus (HPV) vaccination to Peru's cervical cancer screening program. METHODS Evidence (e.g., coverage, delivery costs) from an HPV vaccination demonstration project conducted in Peru was combined with epidemiological data in an empirically...