Although often supersaturated with mineral salts such as calcium phosphate and calcium oxalate, normal urine possesses an innate ability to keep them from forming harmful crystals. This inhibitory activity has been attributed to the presence of urinary macromolecules, although controversies abound regarding their role, or lack thereof, in preventing renal mineralization. Here, we show that 10% ...

This paper describes an estimator of the additive components of a nonparametric additive model with a known link function. When the additive components are twice continuously differentiable, the estimator is asymptotically normally distributed with a rate of convergence in probability of 2 / 5 n− . This is true regardless of the (finite) dimension of the explanatory variable. Thus, in contrast ...

The zeste-white 10 (zw10) and rough deal (rod) genes of Drosophila both encode kinetochore components, and mutations in either gene greatly increase the missegregation of sister chromatids during mitosis. Here, we present genetic, cytological and biochemical evidence for a close, evolutionarily conserved relationship between the ROD and ZW10 proteins. We show that the phenotypes caused by disru...

The probabilistic approach has an important place in the wind energy research field as it provides cheap and fast initial information for experts with the help of simulations and estimations. Wind energy experts have been using the Weibull distribution for wind speed data for many years. Nevertheless, there exist cases, where the Weibull distribution is inappropriate with data presenting bimoda...