Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The need for the administration two to three times a day when larger doses are required can decrease patient compliance. Sustained release formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of metformin. Sustained release products are needed for metformin to pro...

Purpose: To formulate rifabutin-loaded floating gel beads for stomach-specific release. Methods: Rifabutin-loaded floating gellan gum beads were prepared by ionotropic calcium-induced gelation in acidic medium. In-vitro buoyancy and drug release studies were performed using a USP dissolution apparatus type II in 0.01M HCl (ph 2.0) as the dissolution medium. The shape, surface morphology and int...

The purpose of the present investigation was to design and evaluate sustained release tablets of a poorly water soluble drug nifedipine, employing hydrophilic polymers Methocel K15M CR and Methocel K100LV CR and to select the best formulation based on pharmacokinetic studies. Direct compression method was used to prepare matrix tablets. The granules were evaluated for angle of repose, loose bul...

In this study an attempt was made to design and evaluate oral sustained release matrix tablets of ranolazine using Methocel K4M CR as the retardant polymer. Tablets were prepared by conventional wet granulation technique. Tablets were evaluated for parameters such as weight variation, hardness, friability and drug content. All the formulations showed compliance with pharmacopieal standards. In ...

Without resolving mixtures of Cetirizine hydrochloride and Phenylephrine hydrochloride, simultaneous estimation has been successfully achieved by spectrophotometry. First method, simultaneous equation method employs formation and solving of mathematical simultaneous equation using 237.5 nm and 232.0 nm as the λmax of Phenylephrine hydrochloride and Cetirizine hydrochloride respectively in disti...

Polymers like cellulose (MethocelTM K100MPRCR, K15MPRCR and E4MCR) at different proportions (15-35%) were used to slow the release of theophylline (100 mg) from capsules. Volumetric method for powder filling capsules was used to prepare the capsules. Drug release from capsules was performed using apparatus 1, at 100 rpm and 900 mL of intestinal medium without enzymes (pH 7.5), at 37 °C, followi...

Present investigation was aimed at formulation, characterization and evaluation of phytosomal complex tablets for sustained delivery of Phyllanthus amarus complex. Phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient elution with hexane–ethyl acetate solvent mixture. It was obtained in high...

Purpose: To prepare oral sustained release matrix tablets of a highly water soluble drug, tramadol hydrochloride, and to evaluate the effect of concentration of the hydrophobic polymer content and method of preparation on drug release. Methods: The tablets were a mixture of both tramadol hydrochloride and glyceryl palmitostearate (GP) prepared by melt granulation (MG1, MG2, MG3 and MG4 in ratio...