An extension of the H-theorem for dissipative particle dynamics (DPD) to the case of a multi-component fluid is made. Detailed balance and an additional H-theorem are proved for an energy-conserving version of the DPD algorithm. The implications of these results for the statistical mechanics of the method are discussed.

05 for all comparisons). Considering the marked diurnal variations in PICP and ICTP, it may be difficult to interpret the finding of no rhymicity in PINP concentrations. There are no available data in adults or in children for comparison of the finding. Perhaps differences in assay sensitivity and metabolism of the propeptides may play a role, necessitating a larger study population than the pr...

PURPOSE The microRNA miR-27a was recently shown to directly regulate dihydropyrimidine dehydrogenase (DPD), the key enzyme in fluoropyrimidine catabolism. A common polymorphism (rs895819A>G) in the miR-27a genomic region (MIR27A) was associated with reduced DPD activity in healthy volunteers, but the clinical relevance of this effect is still unknown. Here, we assessed the association of MIR27A...

Two dramatic phenomena of human adolescence are sexual maturation and a steep decline in the delta EEG of non-rapid eye movement (NREM) sleep. It has long been speculated that these developmental changes are causally related. Here, we present the first longitudinal data on this issue. Cohorts of 9- and 12-year-old children (n = 31, 38) were studied with in-home sleep EEG recordings at 6-mo inte...

High-symbol-rate coherentoptical transceivers suffer more from the critical responses of transceiver components at high frequency, especially when applying a higher order modulation format. We recently proposed neural network (NN)-based digital pre-distortion (DPD) technique trained to mitigate response 128 GBaud optical coherent transmission system. In this paper, we further detail work and as...

Digital predistortion (DPD) is used to compensate for the distortion of power amplifiers (PAs). Inspired by physical structure PA circuit, a feedback in DPD model favored. In this letter, we proposed an infinite impulse response (IIR) modeling and linearization, modifying generalized memory polynomial (GMP) model. We also propose iterative identification algorithm estimate IIR-DPD coefficients....

BACKGROUND In response to the rapid aging of the population in Japan, many care systems have been created in quick succession. Establishment of discharge planning departments (DPDs) in hospitals is one of them. In this study, we compared the distribution and characteristics of DPDs and the characteristics of the hospitals that have DPDs between 2001 and 2010 in Japan. METHODS We mailed a ques...

Background 99mTechnetium labelled 3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) scintigraphy has been repurposed in recent years as a sensitive non-invasive method for imaging transthyretin (ATTR) cardiac amyloid. We have routinely performed DPD scans since June 2010 at the National Amyloidosis Centre in London, and review here our findings in a large cohort of mostly British patients.

The efficacy of 5-fluorouracil (5-FU)-based chemotherapy for colorectal cancer (CRC) widely varies among patients; therefore, it is difficult to accurately predict chemotherapeutic responses. Some recent studies have found that key enzymes in the various metabolic pathways activated by 5-FU present potential predictors of treatment outcome. Of these enzymes, thymidylate synthase (TS), thymidine...

5-Fluorouracil (5-FU) is used to treat many aggressive cancers, such as those of the colon, breast, and head and neck. The responses to 5-FU, with respect to both toxicity and efficacy, vary among racial groups, potentially because of variability in the activity levels of the enzyme dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene). In this study, the genetic associations between ...