BACKGROUND Cancer cells typically exhibit large-scale aberrant methylation of gene promoters. Some of the genes with promoter methylation alterations play "driver" roles in tumorigenesis, whereas others are only "passengers". RESULTS Based on the assumption that promoter methylation alteration of a driver gene may lead to expression alternation of a set of genes associated with cancer pathway...

......................................................... ..2 00 INTRODUCTION........................................................20 1 REVIEW OF 1979 INDUSTRY STUDY. ................................... ,204 Driver Record Data Calculated for Three Model Groups ..................... 205 Driver Record: Discounts/Surcharges vs. Accident Differences ............... ,208 Exposure Period Measured i...

Driver fatigue is an ill-defined term in the literature. It has been broadly used to refer to a wide range of driver states, each with different causal mechanisms. Technologies currently exist which enable detection of driver fatigue and interventions that have the potential to dramatically reduce crash probability. The successful implementation of these technologies depends on the cause and ty...

It has been proposed that the current design of in-vehicle displays may not be appropriate for the older driver. This paper describes an empirical, road-based investigation of the benefits to older and younger drivers of providing landmarks within the instructions presented by an in-vehicle navigation system. Thirty two participants navigated a challenging urban route using either landmarks or ...

Driver assistance and information systems become more and more important in modern vehicles. One general aim of these systems is to optimize driver’s current workload, because overload as well as underload can increase errors, lead to critical situations and is furthermore experienced as unpleasant for the driver. To prevent these, driver information management systems can coordinate the distri...

When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance mismatch, hence they fail to account for inter-subject variations of the energy...

Vehicle handling and control is an essential aspect of intelligent driver assistance systems, a building block of the upcoming generation of ”smart cars”. A car’s handling is affected by (i) technological (engine, suspension, brakes, tires, wheels, steering, etc.), (ii) environmental (road condition, weather, traffic, etc.), and (iii) human (attentiveness, reactiveness, driver agility, etc.) fa...

The aim of this work is the creation of a realistic driver model to help develop new technologies to aid drivers in the execution of their driving tasks. A realistic driver model can reduce the time-consuming trial and error process of designing products, and thereby reduce the vehicle’s development time and cost. The overall goal of this research is to develop an interface between driver and v...

Modern vehicles are designed to protect occupants in the event of a crash. However, passenger protection can be combined with collision avoidance. Statistics have shown that human error is the number one contributor to road accidents. Advanced driver behavior and monitoring systems have been developed by manufacturers in recent years and many have been proven to be effective systems in the prev...

In the development of driver adaptive and context aware active safety applications, driver–vehicle interaction signals offer excellent opportunities for advanced system design, yet limited progress has been realised. The implementation of driver adaptive and context aware systems requires longer time windows to analyse the current status of the driver and/or traffic situation ahead. In this stu...