نتایج جستجو برای: drug accumulation
تعداد نتایج: 726518 فیلتر نتایج به سال:
HTI-286, a synthetic analogue of hemiasterlin, depolymerizes microtubules and is proposed to bind at the Vinca peptide site in tubulin. It has excellent in vivo antitumor activity in human xenograft models, including tumors that express P-glycoprotein, and is in phase II clinical evaluation. To identify potential mechanisms of resistance induced by HTI-286, KB-3-1 epidermoid carcinoma cells wer...
With the advancements in Artificial intelligence (AI) and accumulation of healthrelated big data, it has become increasingly feasible commonplace to leverage machine learning technologies analyze clinical omics metadata assess possibility adverse drug reactions or events (ADRs) course discovery. Here, we have described a novel approach that combined drug-induced gene expression profile from Ope...
This study was undertaken to find out the interpretation learning strategies employed by successful interpretation learners to achieve the completeness of interpretation. The results showed that, to achieve the completeness of interpretation, they employed knowledge-accumulation, summarization, note-taking and logical-analysis learning strategies, among which the first three learning strategies...
A mitoxantrone-resistant human MCF-7 breast cancer subline (MCF/MX) which is approximately 4000-fold resistant to mitoxantrone was isolated by serial passage of the parental wild-type MCF-7 cells (MCF/WT) in stepwise increasing concentrations of drug. MCF/MX cells were also approximately 10-fold cross-resistant to doxorubicin and etoposide but were not cross-resistant to vinblastine. Intracellu...
results the number of s. pneumoniae isolates resistant to benzylpenicillin, imipenem, oxacillin and ceftazidime were 94.5%, 100%, 100%, and 21.8%, respectively. analysis of mutation in the genes for pbp showed that 85% of isolates had mutations in pbp2x, pbp2b and pbp1a. susceptibility to benzylpenicillin was decreased once the number of mutated pbp genes in s. pneumonia increased. according to...
Miltefosine (hexadecylphosphocholine, MIL), registered as Impavido((R)), has become the first oral drug for the treatment of visceral and cutaneous leishmanasis. MIL is a simple molecule, very stable, relatively safe and highly efficient in clinical trials. However, MIL requires a long treatment course (28 days) and has a long half-life (around 150h), which might accelerate the emergence of dru...
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