The objective of this study was to investigate the effect of multiple-dose sertraline on the pharmacokinetic profile of carvedilol in rats. Carvedilol was orally administrated in rats (3.57 mg/kg body mass (b.m.)) on the absence of sertraline or after a pre-treatment with multiple oral doses of sertraline (7.14 mg/kg b.m.). The plasma concentrations of carvedilol were estimated by HPLC-MS. Afte...

This paper develops a model of intellectual labor augmentation to explain both the marriage wage premium and educational assortative mating. We suggest that husbands and wives are complementary factors of production where a spouse’s education and skills augment their partner’s productivity and earnings potential. We test this proposition using data from the 2000 U.S. Census of Population and th...

Object classification is a very demanding field in computer vision, especially when dealing with medical imaging datasets, which are often small and have unbalanced distributions. Deep learning (DL) methods have proven to be effective in dealing with such problems and have established themselves as the state-of-the-art. ImageCLEFtuberculosis is a challenge that encompasses the classification pr...

Vision is the sense that we use to navigate the world around us. Thus it is not surprising that blindness is one of people's most feared maladies. Heritable diseases of the retina, such as age-related macular degeneration and retinitis pigmentosa, are the leading cause of blindness in the developed world, collectively affecting as many as one-third of all people over the age of 75, to some degr...

In this paper, we present a data augmentation method that generates synthetic medical images using Generative Adversarial Networks (GANs). We propose a training scheme that first uses classical data augmentation to enlarge the training set and then further enlarges the data size and its diversity by applying GAN techniques for synthetic data augmentation. Our method is demonstrated on a limited...

BACKGROUND There is considerable variation in the planning and implementation process for breast augmentation. Although general guidelines are available, the distinctive characteristics of the Natrelle 410 breast implant warrant surgical guidelines specific to this device. This study aimed to develop consensus recommendations for patient selection and preoperative planning for Natrelle 410 in p...

Magdalena Ridge Observatory (MRO) Interferometer is a ten telescope optical interferometer array being built on the Magdalena Mountains 20 miles west of Socorro, New Mexico. The interferometer is being designed by collaboration between New Mexico Institute of Mining and Technology and the University of Cambridge. The science mission and requirements have been finalized which has helped to begin...

It is often difficult to determine whether a patient may best benefit by augmenting their current medication or switching them to another. This post-hoc analysis compares patients' clinical and functional profiles at the time their antipsychotic medications were either switched or augmented. Adult outpatients receiving oral antipsychotic treatment for schizophrenia were assessed during a 12-mon...

Lanzhou New District is the first and largest national-level new district in the Loess Plateau region of China. Large-scale land creation and rapid utilization of the land surface for construction has induced various magnitudes of land subsidence in the region, which is posing an increasing threat to the built environment and quality of life. In this study, the spatial and temporal evolution of...