today hydrogels are considered as the materials that are able to play important role in drug delivery systems. to design an effective hydrogel applicable network, mathematical modeling has a critical role. a successful drug delivery device relies not only on intelligent network design but also on accurate prior mathematical modeling of drug release profiles. in this study, the modeling of the i...

A series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (HQSAR) analysis. A training set containing 24 compounds served to establish the HQSAR model. The best HQSAR model was generated using atoms, bond, connectivity, donor and acceptor as fragment d...