Drug development is very time consuming and costly process. Only few candidates enters in to clinical trials can eventually become a drug. Accurate prediction of the right dose before entering in to clinical study can reduce time as well as cost of drug discovery process. Pharmacokinetic plays an essential role in the selecting the right dose and dosage regimen [1-5]. Thus early prediction of h...

A new, rapid, economical and isocratic reverse phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of eptifibatide acetate, a small synthetic antiplatelet peptide, in bulk drug substance and pharmaceutical dosage forms. The developed method was validated as per of ICH guidelines. The chromatographic separation was achieved isocratically on C18 colum...

Here in this paper, we report a 31-year-old case admitted with symptoms of hyperthyroidism that was then diagnosed with Grave's disease (GD) and underwent treatments with a low dosage of methimazole (10 mg/day). 20 days after treatments initiations, she developed antithyroid arthritis syndrome. This patient experienced arthritis and arthralgia in at least 4 joints. And all autoimmune and microb...

The pharmacist, both in community and hospital pharmacy practice, is often challenged with the preparation of a liquid dosage form not available commercially for paediatric patients, those adults unable to swallow tablets or capsules and patients who must receive medications via nasogastric or gastrostomy tubes. Recognising the lack of information available to healthcare professionals, a genera...

In veterinary drug development procedures, pharmacokinetic (PK) and pharmacodynamic (PD) data have generally been established in separate, parallel studies to assist in the design of dosage schedules for subsequent evaluation in clinical trials. This review introduces the concept of PK/PD modelling, an approach in which PK and PD data are generated in the same study, and used to derive numerica...

drug utilization evaluation (due) studies facilitate assessing the appropriateness and rational use of medications.the goal of the present study was to evaluate amphotericin b usage in neutropenic patients. a prospective due study was performed in hematology-oncology and stem cell transplantation wards at taleghani hospital for one-year. national comprehensive cancer network, clinical practice ...

Simvastatin is a hypolipidemic drug used with exercise, diet and weight – loss to control elevated cholesterol or hypercholesterolemia. It is a member of the Statin class of pharmaceuticals. This paper delives voltammetric techniques is an electrochemical technique used in analytical applications and fundamental studies of electrode mechanism. This review summarizes some of the recent developme...

propranolol, a prototypical b-adrenergic receptor antagonist and atenolol, a cardio-selective b-antagonist are widely used in therapeutic regimens for treatment of hypertensive patients. in iran, several pharmaceutical manufacturers formulate these two b-blockers. as the formulation of a dosage form is essential for the patient's safety and drug efficacy, in this study we aimed to evaluate...

A case of tocainide-induced nodal bradycardia in standard recommended dose is reported. There was no recurrence when the drug was subsequently reintroduced in a reduced dosage. It is suggested that in the elderly, tocainide should be used in a lower dosage than normally recommended.

Abstract: Introduction: Tablet is the preferred drug dosage form. Cellulose fiber (Micro Crystalline Cellulose) major excipient used. For chronic diseases, frequent required resulting in cumulative load and tachyphylaxis due to drug. We intent invent excipients from vegetable sources mitigate above challenges reduce as sufferers (Diabetes mellitus) requires lifelong treatment. Aims Objectives: ...