Drug-induced immune hemolytic anemia is considered to be rare but is likely underrecognized. The consulting pathologist plays a critical role in integrating serologic findings with the clinical history, as drug-induced antibodies should be distinguished as either drug-dependent or drug-independent for appropriate clinical management. Drug-dependent antibodies (DDABs) are most commonly associate...

We use self-consistent N-body models, in conjunction with models of test particles moving in galaxy potentials, to explore the initial effects of interactions on the rotation curves of spiral galaxies. Using nearly self-consistent disk/bulge/halo galaxy models (Kuijken & Dubinski 1995), we simulate the first pass of galaxies on nearly parabolic orbits; we vary orbit inclinations, galaxy halo ma...

Expectations have been shown to be powerful modulators of pain [1] and emotion [2] in placebo studies. In such experiments, expectations are induced by instructions combined with manipulation of the sensory experience that is unknown to the subjects. After an expectation learning phase where a painful stimulation is surreptitiously lowered following placebo application, the placebo effectively ...

present study reports analgesic activity of petroleum ether, chloroform, ethyl acetate and methanolic extracts of leaves and seeds of trigonella foenum-graecum linn. (fabaceae) using hot plate method for evaluation of central analgesic activity and acetic acid induced writhing test for evaluation of peripheral analgesic activity in mice.   all the extracts of trigonella foenum-graecum showed si...

methanolic extract of solanum trilobatum linn. (mest) belonging to the family of solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. the extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...

Hydrophobic grade fumed silicas are generally used in tabletting as lubricants. They are also found to retard the release of pharmaceutical actives. This is because of their hydrophobic nature, which gives good cohesive and adhesive properties. considering this point it was thought that they could be used as dry coating agents for solid dosages forms. The model drug selected for this work was p...

BACKGROUND Surgery with pedicle screw instrumentation does not provide sufficient torsional stability. This leads to pseudoarthrosis, loosening of the pedicle screws, and, ultimately, implant failure. MATERIAL AND METHODS Functional spinal units from 18 deer were evaluated using a 6-axis material testing machine. As specimen models, we prepared an intact model, a damaged model, a cross-rod mode...

Fixed drug eruption is an uncommon adverse drug reaction caused by delayed cell-mediated hypersensitivity. Levocetirizine is an active (R)-enatiomer of cetirizine and there have been a few reports of fixed drug eruption related to these antihistamines. We experienced a case of levocetirizine-induced fixed drug eruption and cross-reaction with other piperazine derivatives confirmed by patch test...