UNLABELLED The blood-brain barrier (BBB) blocks the passage of active molecules from the blood which makes drug delivery to the brain a challenging problem. Oral drug delivery using chemically modified drugs to enhance their transport properties or remove the blocking of drug transport across the BBB is explored as a common approach to address these problems, but with limited success. Local del...

Article history: Received on: 30/08/2013 Revised on: 03/10/2013 Accepted on: 15/10/2013 Available online: 31/10/2013 Azathioprine loaded gelatin microspheres were formulated to control/target drug release in an arthritic joint by magnetic force or intra-articular injection. Glutaraldehyde cross linked microspheres were characterized for drug loading, entrapment efficiency, gas chromatography, m...

A comparative study of the loading and retention properties of three structurally very closely related vinca alkaloids (vincristine, vinorelbine and vinblastine) in liposomal formulations has been performed. All three vinca alkaloids showed high levels of encapsulation when accumulated into egg sphingomyelin/cholesterol vesicles in response to a transmembrane pH gradient generated by the use of...

BACKGROUND Solid lipid nanoparticles (SLN), novel drug delivery carriers, can be utilized in enhancing both intestinal permeability and dissolution of poorly absorbed drugs. The aim of this work was to enhance the intestinal permeability of sulpiride by loading into SLN. METHODS A unique ultrasonic melt-emulsification method with minimum stress conditions was used for the preparation of SLN. ...

This study proposed a drug delivery system based on a series of formulations with chitosan gels, designed for local, intra-pocket treatment of periodontal disease, containing two drugs (an antibiotic and a chimiotherapeutic-antimicrobian agent: tetracycline hydrochloride (T) and metronidazole benzoate (M), respectively. The formulations varied from the chitosan concentration (3-4%), and the dru...

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 3(2) full factorial design was employed with two polymers: Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesio...

Nanofibrous systems are attracting increasing interest as a means of drug delivery, although a significant limitation to this approach has been manufacture on a scale commensurate with dosage form production. However, recent work has suggested that nanofibers may be successfully manufactured on a suitable scale using the novel process of pressurized gyration (PG). In this study, we explore the ...