OBJECTIVES Some patients with deliberate drug poisoning subsequently have an adverse clinical course. The present study aimed to examine whether the type of drugs ingested and psychiatric diagnoses were related to an adverse clinical course. METHODS We conducted a cohort study of patients with deliberate drug poisoning admitted to the intensive care unit of a university hospital located in To...

Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...

Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...

Lomustine is an oral alkylating drug commonly used for brain tumor patients. Recently, the lomustine-containing PCV polychemotherapy regime (procarbazine, CCNU/lomustine, and vincristine) in combination with radiotherapy has become the standard of care for anaplastic oligodendroglioma with 1p/19q codeletion and high-risk low-grade glioma. Here, we review the literature of all reported cases of ...

Introduction Nationally, deaths due to opioid overdose have continually increased for the past 15 years1. Deaths specifically related to heroin increased more than four-fold between 2002 and 20142. Hospital inpatient discharge data provide information on non-fatal overdoses, but include a significant lag in reporting time3. Syndromic ED visit data provide near real-time identification of public...

Because adenine is effective for managing cases of radiation-induced and drug-induced leukopenia, it may be effective in cases of antipsychotic-induced leukopenia and neutropenia. Here, we report our experience with patients with leukopenia and neutropenia caused by an antipsychotic overdose or discontinuation of lithium carbonate, in whom adenine administration ameliorated the white blood cell...

Brown, K. G. E., McMichen, H. U. S., and Briggs, D. S. (1972). Archives of Disease in Childhood, 47, 104. Tachyarrhythmia in severe imipramine overdose controlled by practolol. A 2a-year-old boy, comatose and having fits after an overdose of imipramine, suffered a respiratory and cardiac arrest from which he was successfully resuscitated. A severe tachyarrhythmia was well controlled by intraven...

BACKGROUND Suicide attempts and non-fatal overdoses are both associated with substance use. The aim of the present study was to examine correlates of suicide attempts and non-fatal overdoses simultaneously among individuals seeking addictions treatment. METHODS A large U.S. national sample of individuals entering addictions treatment participated in a cross-sectional survey (n=5892). Multinom...

BACKGROUND The increase in the quantities of central nervous system (CNS)-acting medications prescribed has coincided with increases in overdose mortality, suicide-related behaviors, and unintentional deaths in military personnel deployed in support of the wars in Iraq and Afghanistan. Data on the extent and impact of prescribing multiple CNS drugs among Iraq and Afghanistan Veterans (IAVs) are...

The death of Philip Seymour Hoffman from a heroin overdose tragically adds another name to the list of celebrities who have lost their lives to addiction. Increasing numbers of overdoses from prescription opioids and a more recent increase in heroin-associated fatalities have caused heartbreak in communities across the country. More than 30 000 deaths from unintentional drug overdose were repor...