background: to compare the efficacy of metronidazole versus placebo in the control of gaseous symptoms inpatients with functional bowel disease. materials and methods: in the absence of organic or systemic diseases, all cases with chief complaints of bloating and normal laboratory tests were consecutively enrolled in this double-blind study. lactase deficiency and bacterial overgrowth were rule...

INTRODUCTION Few studies have focused on therapeutic as well as side effects of tranexamic acid (TXA) as a topical drug compared to other topical drugs in treating melasma. The present study aimed to assess and compare the beneficial therapeutic effects and also side effects of local TXA in comparison with hydroquinone in treating women with melasma. METHODS This randomized double-blinded cli...

aim: in this study, the effect of the essential oil of rosa damascena on human colon cancer cell line (sw742) and human fibroblast cells has been reported. background : colon cancer is the second lethal disease after lung cancer. owing to the existence of many side effects and problems related to common treatments such as surgery, chemotherapy and radiotherapy, better substitution is highly nee...

The molecular mechanism of many drug side-effects is unknown and difficult to predict. Previous methods for explaining side-effects have focused on known drug targets and their pathways. However, low affinity binding to proteins that are not usually considered drug targets may also drive side-effects. In order to assess these alternative targets, we used the 3D structures of 563 essential human...

Abstract Background Development of pharmaceutical interventions for schizophrenia emphasizes clinical efficacy and subsequent effectiveness cost-effectiveness. However, given the many side effects antipsychotic medication, it is important to consider importance different on preferences that people with have drugs. This study aims use a discrete choice experiment elicit patient medication profil...

Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of a fixed or adjusted dose of vitamin E on the side effects of acitretin. Patients and Methods: Fi...

Purpose RLS is a common sleep disorder that negatively affects health, well-being, and quality of life. Although standard drug treatments for RLS can carry serious side effects, promising nonpharmacologic therapies, while widely recommended, remain little investigated. In this pilot pre-post trial, we assessed the effects of a gentle 8-week yoga program on RLS symptoms and related outcomes in w...