Objective: Febuxostat, a xanthine oxidoreductase inhibitor, is a drug of choice for hyperuricemia and Gout. But it also suffers from drawbacks in terms of pharmacokinetic profile and toxicity. It is available as immediate release formulation in the market. The objective is to develop a modified release formulation of febuxostat that can serve the dual purpose of increasing the efficacy and decr...

background the treatment of posterior eye diseases is always challenging mainly due to inaccessibility of the region. many drugs are currently delivered by repeated intraocular injections. objectives the purpose of this study was to investigate the potential applications of natural triglycerides as alternative carriers to synthetic polymers in terms of drug release profile and also biocompatibi...

Background: A novel drug delivery system using poly (ε-caprolactone) - poly (ethylene glycol) -poly (ε-caprolactone) (PCL-PEG-PCL) was established in this study. Methods: Ceftriaxone (CTX) was encapsulated within PCL-PEG-PCL nanoparticles by a double emulsion technique (w/o/w), leading to creation of ceftriaxone-loaded PCL-PEG-PCL (CTX/PCL-PEG-PCL) polymersomes. The resulting polymersomes...

the objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (ir) and modified release (mr) tablets. the experiment included rats with both normoglyceamia and streptozocin (stz)-induced hyperglyceamia. several mr formulations were designed and in vitro drug release profile was assessed by a dissolution test. for the fur...

During the last two decades, hydrophilic swellable polymers have been widely used to control the release of a drug from matrix tablet formulations. The increasing need for suitable polymers to achieve the desired drug release profile conducted the pharmaceutical research to widely screening a large variety of both synthetic and natural polymers which show drug release retarding ability. Because...

Rivastigmine, an anti-Alzheimer’s drug, is effective in the treatment of mild to moderate dementia. Oral immediate release (IR) formulation suffers from limitation like severe GI adverse effects which may even result in treatment interruption, like vomiting, diarrhea and anorexia resulting in wide fluctuations in drug plasma levels and calling for altered frequency of dosing. Even the Novel Dru...

Atenolol, an antihypertensive drug, has poor bioavailability (40-50%) and has has low elimination half life(6 hr). Atenolol is mainly absorbed in the stomach. The floating tablets of atenolol were prepared to increase the gastric retention, extend the drug release and to improve the bioavailability of the drug. The floating tablets were formulated using HPMC 100 cps, sodium alginate, carbopol 9...

determining biological equivalence between pioneer and generic products, checking equivalence after change in batch size, detecting changes in components or composition, and checking equivalence after modification of manufacturing equipment or processes. The test method has also been suggested as a possible standard for quality control of topical drug products. We thus established an in vitro d...

The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated. Attenuated total reflectance Fourier transform infrared...

Restenosis (renarrowing of the blood vessel wall) and cancer are two different pathologies that have drawn extensive research attention over the years. Antiproliferative drugs such as paclitaxel inhibit cell proliferation and are therefore effective in the treatment of cancer as well as neointimal hyperplasia, which is known to be the main cause of restenosis. Antiproliferative drugs are highly...