Nimodipine (NMP), a Ca channel blocker, has a low oral bioavailability due to poor solubility and insufficient dissolution rate. In order to improve the same, various techniques were employed viz., evaporative precipitation into aqueous solution (EPAS), spherical agglomeration (SA) and solid dispersion using solvent evaporation and meltmixing. Formulations so prepared were characterised by diff...

Of all the pharmaceutical compounds, about 40% are considered poorly water soluble and hence, the development of efficacious formulation is being halted. It has been shown that a drug should have a minimum aqueous solubility of 1% to avoid bioavailability problems. During preformulation study, sufficient time should be invested in order to improve the solubility of these kinds of drug. At the v...

Silymarin is a hepatoprotective agent, having poor water solubility and oral absorption of about 23 - 47%, leading to low bioavailability of the drug. The aim of the present study is to improve the solubility and dissolution rate and in turn the hepatoprotective activity of the drug, by formulating its inclusion complex with beta (β)-cyclodextrin, using different methods. The phase solubility a...

The lung is an attractive target for drug delivery due to noninvasive administration via inhalation aerosols, avoidance of first-pass metabolism, direct delivery to the site of action for the treatment of respiratory diseases, and the availability of a huge surface area for local drug action and systemic absorption of drug. Colloidal carriers (ie, nanocarrier systems) in pulmonary drug delivery...

The issues of solubility for the targeted drug delivery new affects, many existing drug. minimum 40% novel from pharmaceutical industries are showing poor ability solubilization in water. Hence to increase such waters and their bioavailabilities major challenges scientists. So overcome problems dissolution, development solid dispersion with carriers having good water is beneficiary. methods fou...

The prospect of improved cancer therapy using Solid Lipid Nanoparticles (SLNs) as drug delivery system is promising. Several obstacles frequently encountered with anticancer compounds, such as poor drug solubility, are overcome by delivering them using SLN. Moreover, the intravenous administration of drugs into SLNs can potentially enhance drug blood circulation time and improve drug performanc...

The aim of this study was to improve the water solubility of raloxifene by complexing it with sulphobutylether-β-cyclodextrin. Inclusion complexation in aqueous solution and solid state was evaluated by the phase solubility diagram, powder X-ray diffractometer, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, scanning electron microscopy, hot stage microscopy and transmissio...