A drug substance or drug product can be exposed to natural or artificial light during production, storage, administration and use. The great majority of drug substances and pharmaceutical excipients absorb UV and possibly visible radiation. Absorption is a first indication that a compound may participate in a photochemical process i.e. be photoreactive, which can result in its own decomposition...

Substance abuse has been a thorny public health concern throughout human history. Manifestly, prevention and treatment are the two main strategies commonly adopted to tackle problem of substance abuse. They in fact cross-disciplinary, they relate various domains heredity, biology, psychology, cognitive science, family, social development cultural structures. Almost everyone, directly or indirec...

OBJECTIVE Atypical sequences of drug use progression are thought to have important implications for the development of substance dependence. The extent to which this assumption holds for South African populations is unknown. This paper attempts to address this gap by examining the prevalence and correlates of atypical patterns of drug progression among South Africans. METHOD Data on substance...

Substance abuse in adolescents is undertreated in the United States. Family physicians are well positioned to recognize substance use in their patients and to take steps to address the issue before use escalates. Comorbid mental disorders among adolescents with substance abuse include depression, anxiety, conduct disorder, and attention-deficit/ hyperactivity disorder. Office-, home-, and schoo...

A wide range of population-based and clinical studies in the literature consistently demonstrate that substance use/dependence is one of the most common mental health-related disorders (Cohen et al, 1999; Coulthard et al, 2002; Crawford et al, 2003). A national study of psychiatric comorbidity in the UK found that the prevalence of dependence on any drug was 4% and dependence on cannabis was re...

BACKGROUND Substance use is associated with numerous undesirable short and long term consequences. The individual not only suffer from physical and psychological problems but also loses the ability to interact with family, peers and society. The present study aims to identify the psychosocial problems and associated factors among individuals with substance use disorders. METHODS The study was...

Alcohol and other drug (AOD) use plays a major role in the acquisition and spread of HIV, and the majority of women living with HIV are either active or recovering drug users. Forty-six percent of women's cases of HIV infection have been attributed to injection-drug use and 18% to women's heterosexual contacts with injection-drug users. Substance abuse often contributes to noncompliance with HI...

A comparison of the polymorphic forms of 3 commercial sources of fusidic acid using FTIR and XRPD techniques has been performed in this study. It has been demonstrated that polymorphic Forms I and III are currently available on the commercial market. The influence of the observed polymorphism on the stability of the drug substance in bulk form has been investigated through stability and stress ...

BACKGROUND The use of methamphetamine and other drugs among young adults has been a theme of growing interest and concern on the part of researchers and health associations. This paper reports recent use of methamphetamine and its relation with some demographic variables among substance users in west of Iran. METHODS This cross-sectional study was carried out on 559 substance users of Hamadan...