The indole heterocycle represents one of the most important scaffolds in medicinal chemistry and is shared among a number drugs clinically used different therapeutic areas. Due to its varied biological activities, high unique chemical properties significant pharmacological behaviors, derivatives have drawn considerable interest last decade as antitumor agents active against types cancers. resea...

Abstract Background HIV-infection, tuberculosis and malaria are the big three communicable diseases that plague sub-Saharan Africa. If these occur as co-morbidities they require polypharmacy, which may lead to severe drug–drug-gene interactions variation in adverse drug reactions, but also treatment outcomes. Polymorphisms genes encoding drug-metabolizing enzymes major cause of variations, such...