Acute myocardial infarction (AMI) is one of the main leading causes of mortality and morbidity. Despite the progress in the treatment of AMI, streptokinase is still being used in many countries. Because of the critical condition of patients with AMI and complications of streptokinase therapy, this study was performed to evaluate the pattern of adverse drug reaction (ADRs) induced by streptokina...

Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular diseases and cancer. However, the underlying mechanisms of action remain elusive. Convincing data place energy metabolism at the center of metformin's mechanism of action in diabetes and may also be of im...

For doctors at Memorial Sloan-Kettering Cancer Center in late 2012, it was an easy call. The drug Zaltrap, new on the market (Bach 2012) for treatment of patients with metastatic colorectal cancer, promised to provide an overall survival benefit of 1.4 months compared with a standard chemotherapy regimen. But so did Avastin (bevacizumab) — and the two drugs had similar mechanisms of action, pre...

OBJECTIVE Physicians have been surveyed concerning their satisfaction with poison center services but have never been questioned regarding their expectations. This study was conducted to clarify the expectations of emergency physicians in New Mexico regarding the service of their regional poison center, the New Mexico Poison and Drug Information Center. DESIGN Five New Mexico emergency depart...

background and aims. orofacial pain is one of the most common reasons for attendance at the dental clinic. the prevalence and the sources of orofacial pain vary from place to place and patients’ response to pain also differs. the aim of this study was to determine the prevalence and pattern of orofacial pain as well as the factors influencing patients’ response to orofacial pain among patients ...

Editors' Introduction: HIV and Other Infectious Diseases Among Drug-Involved Offenders James A. Inciardi a , Carl G. Leukefeld b , Steven S. Martin c & Daniel J. O'Connell c a Center for Drug and Alcohol Studies, University of Delaware , Coral Gables, FL b University of Kentucky Center on Drug and Alcohol Research , Lexington, KY c Center for Drug and Alcohol Studies, University of Delaware , N...