A strong correlation exists between inflammatory bowel disease (IBD) and oxidative stress involving alterations of several key signaling pathways. It is known that methionine promotes reactive oxygen species (ROS) production; we therefore hypothesize that a methionine restriction diet would reduce ROS production, inflammatory responses, and the course of IBD. We generated a murine colitis model...

Inflammation is potential risk factor of various human malignancies. Inflammatory bowel syndromes such as ulcerative colitis are well known as risk factors for colon cancer. Here, we examined enhancing effects of dextran sulfate sodium (DSS)-associated inflammation on X-irradiation induced colonic tumorigenesis in Min and wild-type (WT) mice. Animals were X-irradiated at 1.5 Gy at 5 weeks of ag...

PRECISE ANATOMICAL ANALYSIS OF STENOTIC LESIONS OF THE LEFT VENTRICULAR outflow tract (LVOT) in discrete subaortic membranous stenosis (DSS) and hypertrophic obstructive cardiomyopathy (HOCM) is challenging due to their complex nature (1,2). In the present study, we clarified the difference of the geometry and dynamic change of LVOT area using en face views of the LVOT in 6 patients with DSS an...

In this research, a Decision Support System (“DSS”) was developed, using a combination of various existing models for Integrated Water Management (“IWM”). This DSS is then applied to a small urbanized basin, the Taguri-River basin in Japan. In developing the DSS, different existing dynamic and steady state models were combined. These models include a rainfall-runoff analysis model, two river an...

OBJECTIVES We tested the hypothesis that age is a prognostic factor with respect to long-term accumulation of disability in multiple sclerosis (MS). METHODS Kaplan-Meier analysis and binary logistic regression models determined the effect of age at disease onset, age at onset of progression, and current age on attainment of severe disability levels (Disability Status Scale [DSS] 6-8-10) from ...

dss (data stream scan) is a framework for describing, transforming, reading, querying, and writing streams of record oriented data. dss is implemented as a command and library API and used extensively to aid network measurements in our organization. The API is extended by DLLs (shared libraries) that define data domain specific I/O, type and query functions. We provide a best-in-class repositor...

OBJECTIVE This study reports clinical manifestations and spectrum of severity of dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) in adult patients admitted during 2006 outbreak in Karachi. A rough estimation of cost of care was also calculated. METHODS A cross-sectional study was done at a tertiary care hospital in Karachi from January to December 2006. Pati...

A decision support system (DSS) for systematic control of priority pollutants (PP) sources, based on economic activities and production (release) processes in urban catchments was recently developed. One of the crucial functionalities of the DSS is evaluation of source control measures, which is based on mathematical models, used for simulating the fate of the PPs in urban catchments under diff...

Ulcerative colitis (UC) results from colonic epithelial barrier defects and impaired mucosal immune responses. In this study, we aimed to investigate the modifying effects of a Spirogyra neglecta extract (SNE), a polysaccharide extract (PE) and a chloroform fraction (CF) on dextran sodium sulfate (DSS)-induced colitis in mice and to determine the mechanisms. To induce colitis, ICR mice received...

Many immune down-regulatory molecules have been isolated from parasites, including cystatin (cystain protease inhibitor). In a previous study, we isolated and characterized Type I cystatin (CsStefin-1) of the liver fluke, Clonorchis sinensis. To investigate whether the CsStefin-1 might be a new host immune modulator, we induced intestinal inflammation in mice by dextran sodium sulfate (DSS) and...