A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N',N",N"-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded regio...

INTRODUCTION Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) is a quantitative MRI method utilizing anionic contrast agent Gd-DTPA. The suggested mechanism is that the fixed charge density (FCD) of cartilage, induced by glycosaminoglycans (GAG), dictates the contrast agent distribution in cartilage via electrostatic repulsion [1]. The aim of the present study was to investigate the diffe...

Background Recent work demonstrated the feasibility of using realtime MRI to guide right heart cardiac catheterization. In order to make balloon catheters used in the procedure more conspicuous, the balloons were filled with dilute Gd-DTPA, and non-selective saturation pulses were applied along with acquisition of thick slices. The saturation pulses increased the contrast between blood and the ...

Introduction: Pyeloplasty has success rate of up to 98%. We believe that paediatric pyeloplasty even in poorly functioning kidney, will result maximum salvage renal function. The aim our study was evaluate the outcome kidneys with PUJO population. Methods: children a GFR < 30 ml / min or 30% differential function on DTPA, who underwent NU hospitals, Bengaluru over period 11 years 2 months, w...

MRI of brain tumors was performed with CPMG pulse sequence, and T1 and T2 relaxation times were measured before and after the administration of 0.1 mmol/kg Gd-DTPA. T1 and T2 became significantly shorter than before with the T1 shortening being about twice the T2's. Three types of T2 shortening were classified by the difference in the intra-tumoral transport of Gd-DTPA in the time-course study ...

We retrospectively compared the results of 67Ga chest scans and 99mTc-DTPA aerosol clearance measurements with those of fiberoptic bronchoscopy in 88 patients infected with the human immunodeficiency virus. Of 100 investigations, a pulmonary infection was diagnosed in 39, mainly Pneumocystis carinii pneumonia and a noninfectious disorder was found in 42, mainly Kaposi's sarcoma and lymphocytic ...

Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagn...

Measurement of pulmonary clearance of an inhaled aerosol of technetium-99m labelled diethylenetriaminepenta-acetate (DTPA) by external detection methods has been used widely as an index of permeability across alveolar epithelium and bronchial mucosa. To determine the applicability of the tracer to measurement of permeability in the airways the diffusion and binding characteristics of 99mTc DTPA...

A peptide targeted contrast agent, CLT1-(Gd-DTPA), was synthesized for molecular imaging of fibronectin-fibrin complexes in tumor tissue with magnetic resonance imaging (MRI). The T(1) and T(2) relaxivities of CLT1-(Gd-DTPA) were 4.22 and 4.45 mM(-1) s(-1) at 3 T, respectively. The targeted contrast agent specifically bound to tumor tissue and resulted in significant tumor contrast enhancement ...