UNLABELLED In most types of peptide receptor radionuclide therapy, the maximum activity dose that can be administered is limited by high and persistent renal retention of the radiolabeled peptides, which is, at least partly, mediated by the megalin receptor. Several agents that interfere with renal reabsorption of radiolabeled peptides have been identified (e.g., lysine, arginine, succinylated ...

Internalizing agonists are usually selected for peptide receptor targeting. There is increasing evidence that non-internalizing receptor antagonists can be used for this purpose. We investigated whether the glucagon-like peptide-1 receptor (GLP-1R) antagonist exendin(9-39) can be used for in vivo targeting of GLP-1R expressing tumours and compared the in vitro and in vivo characteristics with t...

Direct reactions of the MRI contrast agent K2[Gd(DTPA)(H2O)]·5H2O (1) (H5DTPA = diethylenetriaminepentaacetic acid) with dipotassium hydrogen phosphate (K2HPO4) or phosphite (K2HPO3) result in the isolation of well-defined Gd-DTPA phosphite K6[Gd2(DTPA)2(HPO3)]·7H2O (2) or phosphate K6[Gd2(DTPA)2(HPO4)]·10H2O (3), respectively. Their lanthanum analogs K4[La2(DTPA)2(H2O)]·8H2O (4), K6[La2(DTPA)2...

PURPOSE The feasibility of measuring blood-brain barrier permeability was studied in a 36B-10 brain glioma model in rats. MATERIALS AND METHODS In stage I of our study, sequential MR images of glioma-implanted rats were obtained following intravenous administration of three contrast agents of different molecular sizes--Gd-DTPA, polylysine-(Gd-DTPA), and albumin-(Gd-DTPA). In a second set of e...

SCINTIGRAPHIC VISUALIZATION OF ABDOMINAL LYMPH NODES WITH 99mTc-PERTECHNETATE-LABELED SULFUR COLLOID Virgil F. Fairbanks, W. Newlon Tauxe, Joseph M. Kiely, and W. Eugene Miller 185 EFFECT OF LINE SPACING AND RATEMETER AVERAGING ON LESION DETECTION L. G. Knowles, E. F. Hart, and A. G. Schulz 191 CLINICAL EVALUATION OF °TGa-CITRATE SCANNING T. Higasi, Y. Nakayama, A. Murata, K. Nakamura, M. Sugi...

BACKGROUND The purpose of this study was to clarify the value of renal drainage half-time in the evaluation of pediatric hydronephrosis after dismembered pyeloplasty. METHODS We reviewed the records of 30 children who underwent dismembered pyeloplasty for unilateral ureteropelvic junction obstruction with no other associated urological abnormality. The follow-up duration was more than 5 years...

A chelating agent helps crops to reuse as nutrients by mobilizing salts from the soil. This study was conducted evaluate effects of Diethylenetriamine pentaacetic acid (DTPA), N-(2-hydroxyethyl)-ethylene diaminetriacetic (HEDTA), and Ethylene diamine disuccininc (EDDS) for improving plant growth reusing accumulated in soils plastic film house. Two experiments were carried out follows: i) For in...

BACKGROUND Prenatal hydronephrosis (PNH) is dilation in urinary collecting system and is the most frequent neonatal urinary tract abnormality with an incidence of 1% to 5% of all pregnancies. PNH is defined as anteroposterior diameter (APD) of renal pelvis ≥ 4 mm at gestational age (GA) of < 33 weeks and APD ≥ 7 mm at GA of ≥ 33 weeks to 2 months after birth. All patients need to be evaluated a...