Dynamic treatment regimes (DTR) are a statistical paradigm in precision medicine which aim to optimize patient outcomes by individualizing treatments. At its simplest, DTR may require only single decision be made; this special case is called an individualized rule (ITR) and often used maximize short-term rewards. Generalized dynamic weighted ordinary least squares (G-dWOLS), estimation method t...

Previously, researchers who developed representative driving cycles mainly focused on light-duty vehicles and only considered vehicle speed related derivations. In this paper, we propose a novel approach to develop for heavy-duty vehicles. By implementing decision tree regression (DTR) the Fleet DNA on-road data, broader set of metrics, such as engine power fuel consumption, can be used more ro...

Gli proteins regulate the transcription of Hedgehog (Hh) target genes. Genetic studies in mouse have shown that Gli1 is not essential for embryogenesis, whereas Gli2 acts as an activator of Hh target genes. In contrast, misexpression studies in Xenopus and cultured cells have suggested that Gli1 can act as an activator of Hh-regulated genes, whereas Gli2 might function as a repressor of a subse...

Rehmannia glutinosa, an herb of the Scrophulariaceae family, is widely cultivated in the Northern part of China. The tuberous root has well-known medicinal properties; however, yield and quality are threatened by abiotic and biotic stresses. Understanding the molecular process of tuberous root development may help identify novel targets for its control. In the present study, we used Illumina se...

O presente estudo utilizou a modelagem matemática aliada aos métodos de obtenção das curvas Distribuição Tempo Residência (DTR) para simular o modelo físico um distribuidor em escala 1:5. Foram realizadas três simulações: sem injeção gás, com gás uma posição e quatro posições. método dispersão traçador por pulso foi utilizado análise da curva DTR permitiu do escoamento aÃ...

In this paper, we investigate the age minimization problem for a two-hop relay system, under resource constraint on average number of forwarding operations at relay. We first design an optimal policy by modelling considered scheduling as constrained Markov decision process (CMDP) problem. Based observed multi-threshold structure policy, then devise low-complexity double threshold relaying (DTR)...

Rwanda has experienced high temperature rising phenomena over the last decades and hence, highly vulnerable to climate change. This paper examined spatial temporal variations of daily maximum minimum surface air (Tmin Tmax) diurnal range (DTR). It studied variables at monthly, seasonal annual time-scales from 1961 2014. The study applied various statistical methods such as ordinary least-square...

The transmission of many vector-borne pathogens is strongly influenced by environmental temperature, via effects on the physiology of the insect vector and the pathogen. Therefore, changes in local environmental conditions could significantly impact the distributions and dynamics of a range of vector-borne diseases. Predicting the extent of possible changes in disease dynamics will require a de...