Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to selectively infect, replicate in, and lyse malignant cells without causing harm to normal, healthy tissues. In addition to direct oncolytic activity, OVs have shown dual promise as immunotherapeutic agents. The presence of viral infection and subsequently generated immunogenic tumor cell death trigger inn...

The expression of appropriate ensembles of ionic channels is necessary for the differentiation and normal function of vertebrate neurons. Cell-cell interactions may regulate the expression and properties of ionic channels in embryonic neurons. Previous studies have shown that the expression of A-type K+ channels (IA) and Ca2+-activated K+ channels (lK[Ca]) is abnormal in chick ciliary ganglion ...

Oncolytic viruses (OV) were first observed in early clinical studies in patients with malignancies where tumour regressions were observed to coincide with viral infections or with live virus vaccinations. Since these early reports, studies using OV have progressed from anecdotal and controlled infections to specifically selecting or genetically modifying viruses for cancer treatment. OV are int...

We consider finite element methods based on simplices to solve the problem of nearly incompressible elasticity. Two different approaches based respectively on dual meshes and dual bases are presented, where in both approaches pressure is discontinuous and can be statically condensed out from the system. These novel approaches lead to displacement-based low order finite element methods for nearl...

In this paper, we introduce the concept of dual frame of g-p-frame, and give the sufficient condition for a g-p-frame to have dual frames. Using operator theory and methods of functional analysis, we get some new properties of g-p-frame. In addition, we also characterize g-p-frame and g-q-Riesz bases by using analysis operator of g-p-Bessel sequence. c ©2017 All rights reserved.

A recently reported chitinase gene, expressed in the infective, third-stage (L3) larvae of the human filarial parasite Onchocerca volvulus, belongs to the family 18 glycosyl hydrolases and has been designated Ov-chi-1. The gene product of Ov-chi-1 is chitinolytic. Allosamidin ablates activity of the native enzyme in a dose-dependent manner but did not significantly inhibit the moulting of L3 la...

Functional Near Infrared Spectroscopy (fNIRS) can non-invasively capture dynamic cognitive activation and underlying physiological processes by measuring changes in oxy- and deoxy-hemoglobin levels, correlated to brain activation. It is a portable, inexpensive and user-friendly device which is easily adapted to the outpatient setting for the assessment of cognitive functions after Traumatic Bra...

The aim of this study was to evaluate the oxidative stress in ovaries and corpus luteum (CL) Bos taurus indicus females oxidant effect CL ovarian tissues regions near, intermediate, or distant from it. Ovaries (n=12) Nelore heifers (n=6) were collected a slaughterhouse fragmented. Experiment 1, each ovary obtained three fragments, resulting 18 fragments with (OV+CL) another without (OV-CL). Thr...

Let K be a finite extension of Qp, let L/K be a finite abelian Galois extension of odd degree and let OL be the valuation ring of L. We define AL/K to be the unique fractional OL-ideal with square equal to the inverse different of L/K. For p an odd prime and L/Qp contained in certain cyclotomic extensions, Erez has described integral normal bases for AL/Qp that are self-dual with respect to the...