Abstract Background The deubiquitinase (DUB) family constitutes a group of proteases that regulate the stability or reverse ubiquitination many proteins in cell. These enzymes participate cell-cycle regulation, cell division and differentiation, diverse physiological activities such as DNA damage repair, growth development, response to stress. However, limited information is available on this g...

Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes is becoming ever clearer as new roles are elucidated and new pathways are shown to be affected by this mechanism. Recent work, reviewed in the present paper, provides new perspective on the widening influence of Dubs and...

Lawrence Lessig called the most recent battle ‘‘Hollywood v. Silicon Valley,’’1 but one could just as well dub it ‘‘Code v. The Common Law.’’ The content industries’ latest efforts to re-calibrate the balance of copyright2 imply that the United States copyright system has reached a crisis that cannot be resolved under existing law. In particular, bills such as the Consumer Broadband & Digital T...

In this article, the authors explore why medical device innovation has traditionally been geared so thoroughly toward improving performance, with little regard to cost. They argue that the changing incentives in the health care sector and the move to value-based payment models, accelerated by the implementation of the Affordable Care Act, will force device manufacturers to redirect investments ...

Abstract Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve efficacy of current therapies. In hepatocellular carcinoma (HCC), aberrant expression hypoxia-inducible factor 1 α (HIF1α) and increased aerobic glycolysis metabolism are drivers therapy with multi-kinase inhibitor Sorafenib. However, it has remained unknown how HIF1α activated its ...