We evaluated the clinicopathological features and prognosis of 29 cases of prostate ductal carcinoma was considered to be an aggressive subtype of prostate acinar carcinoma. We selected 29 cases who were diagnosed prostate ductal carcinoma and had a radical prostatectomy (RP). The acinar group (n = 116) was selected among 3,980 patients who underwent a prostatectomy. The acinar group was matche...

malformations which occur during the development of the avian body organs can lead to structural and functional abnormalities. most defects are recognized at hatching, but some go undetected until somewhat later. the cause of the majority of animal congenital malformations is unknown. a significant proportion of congenital malformations of unknown cause are likely to have an important genetic c...

holt-oram syndrome (hos) is a developmental disorder inherited in an autosomal-dominant pattern. affected organs are the heart and forelimbs with upper extremity skeletal defects and congenital heart malformation. in this study we present three cases of hos in the same family. in one of these three individuals we detected a transition of c to t (ctg-gtt, v205v) in exon 7 of the tbx5 gene. this ...

BACKGROUND Newborns with obstructive left heart lesions often depend on a patent ductus arteriosus to sustain the systemic circulation. Our aims were to validate the direct measurement of ductal flow, and to characterize the magnitude, determinants and hemodynamic effects of patent ductus arteriosus in newborns with obstructive left heart lesions by cardiovascular magnetic resonance (CMR). ME...

Neurologic sequalae of Noonan syndrome have been postulated in the literature. A topic significance is role RASopathy shared pathophysiology Syndrome and Chiari I malformation. In this unique case report, we present a patient with concomitant 4th ventricular outflow obstruction. The highlights importance close clinical suspicion population. We utilize to delve into intricacies known encourage o...

Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit. One of the best examples for this functional unit is the regulation of luminal pH by both cell types. Protons co-released during exocytosis f...

INTRODUCTION Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of several molecular markers in breast cancer has been of considerable interest during recent years such as p53 and estrogen receptor alpha (ERalpha). However, p53 nuclear accumula...

Cerebral cavernous Malformation (CCM) is a rare neurovascular malformation accounting 0.5% to 4% of all intracranial vascular malformations. People harboring CCM may be symptomatic or present with seizure, hemorrhage progressive neurological deficit. Asymptomatic needs no treatment. The not require intervention. best treatment for microsurgical excision. Over period five years we have been mana...

We studied the pattern of E-cadherin expression in 183 invasive carcinomas (100 ductal, 42 lobular, 41 with mixed ductal and lobular features) and 198 in situ carcinomas (131 ductal, 53 lobular, 14 in situ with ductal and lobular features) by immunohistochemistry. We found a highly significant correlation of E-cadherin membrane expression with the histologic phenotype of the tumors. While moder...

A 21-year-old mentally retarded male was admitted to our department with abdominal swelling. A physical examination revealed mental retardation and nystag-mus. The liver and spleen were 7 and 15 cm palpable, respectively. Ascites and edema of the leg were not detected. There was marked ataxia. Other findings of the physical examination were normal. Blood test results included hemoglobin: 12.2 g...