OBJECTIVE To assess the relation between serum leptin levels and lipid profile in women with pre-eclampsia and to evaluate their atherogenic role in the pathophysiology of pre-eclampsia. METHODS This was a comparative cross-sectional study, carried out in the Department of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre (JPMC), in collaboration with the depart...

Publisher's statement This is the author’s version of a work that was accepted for publication in Clinical Neurophysiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A de...

Objectives: Prevention of sudden cardiac death is the number one clinical priority in sports cardiology. While the overall cardiovascular risk of long distance running is acknowledged as low, the frequency of cardiac arrests and sudden death has increased in middle-aged males during marathons since the year 2000. An evidence-based strategy for protecting susceptible runners from these acute car...

Worldwide water shortage increase and water quality depletion from microbial and chemical compounds, pose significant challenges for today's water treatment industry. Both the development of new advanced oxidation technologies, but also the enhancement of existing conventional technologies is of high interest. This study tested improvements to conventional ozonation that reduce the formation of...

 Success of pregnancy depends on many factors. Three phenomena inducing immune tolerance against semi-allogeneic conceptus may play a crucial role in the pre-implantation period of pregnancy: influence of sex hormones in sex cycle, presence of oocyte or embryo and the presence of semen in the female reproductive tract. On the other hand dendritic cells are the most effective antigen-presenting ...

Embryonic stem cells (ESCs) are pluripotent cell lines that can be maintained indefinitely in an early developmental state. ESC culture conditions almost always require the cytokine LIF to maintain self-renewal. As ESCs are not homogeneous but contain multiple populations reminiscent of the blastocyst, identifying the target cells of LIF is necessary to understand the propagation of pluripotenc...

The 5' splice site of a pre-mRNA is recognized by U1 small nuclear ribonucleoprotein particles (snRNP) through base pairing with the 5' end of U1 small nuclear RNA (snRNA). Single-base substitutions within a 9-nucleotide 5'-splice-site sequence can abolish or attenuate use of that site and, in higher eukaryotes, can also activate nearby "cryptic" 5' splice sites. Here we show that the effects o...

Although the risks smoking poses to health are now well known, many young people continue to take up the habit. While numerous cross-sectional studies of adolescents have identified correlates of smoking initiation, much less prospective, longitudinal research has been conducted with young children to gather their accounts of early experiences of smoking, and this study fills that significant g...

The heart rates of 20 movement studies students were measured during multi-stage cycle ergometer tests. The tests were repeated on five occasions following the ingestion of different pre-exercise meals and the results compared. A glucose solution taken three hours prior to the exercise (G3) resulted in the lowest heart rates at each work rate. The highest heart rates at each work rate were reco...

In this paper we address the problem of realizing the benefits of pre-computed schedules in the face of a partially unpredictable execution environment. We focus specifically on the problem of manufacturing production scheduling, where advance planning is crucial to overall factory performance but is, at the same time, confounded by the unpredictability of factory operations. We present a sched...