We are using the glycolytic enzyme aldolase as a marker to investigate the molecular basis for reduced levels of specific enzyme activities associated with muscular dystrophy. Inbred strains of normal and dystrophic chickens were used as models to study the disease. In the present paper we show that: 1) aldolase & was the only isoenzyme present in normal and dystrophic muscles derived from lto ...

Beginning on day 4 ex ovo, and every 3 d thereafter, genetically dystrophic Line 413 chickens were given intraperitoneal injections (4 mg/kg body wt) of a protease inhibitor, leupeptin, pepstatin, or antipain. Experimental chickens received protease inhibitors dissolved in a water:ethanol:dimethyl sulfoxide solution (50:40:10, vol:vol:vol). Control untreated animals received diluent injections....

1. The composition and metabolism of phospholipids were studied in various tissues from both normal and dystrophic mice of the 129 ReJ strain. Phospholipids extracted from forebrain, spinal cord, sciatic nerve and plasma were fractionated by t.l.c. and measured. 2. Very significant alterations were found in the choline phospholipids from these tissues, except forebrain. Plasma phosphatidylcholi...

1927-60: reports of 10 cases 1964: Samman and White describe the condition and coin the term 'yellow nails'.' This is the first description of a new syndrome of slow-growing nails with a characteristic appearance and oedema, usually affecting the ankles 1966: the syndrome is defined as the presence of a triad of yellow nails, lymphoedema and pleural effusion2 1972: the presence of two of the th...

Distraction osteogenesis has been used for more than 50 years to address limb-length discrepancy and deformity. Intramedullary fixation has been used in conjunction with external fixation to decrease the time in the external fixator and prevent deformity and refracture. A new generation of motorized intramedullary nails is now available to treat limb-length discrepancy and deformity. These nail...