Abstract The human papillomavirus (HPV) is recognized as the main etiologic agent associated with cervical cancer. HPVs are epitheliotropic, and ones that infect mucous membranes classified into low-risk (LR) high-risk (HR) types. LR-HPVs produce benign lesions, whereas HR-HPVs lesions may progress to HR-HPV types 16 18 most frequently found in cancer worldwide. E6 E7 major HPV oncogenic protei...

Membrane-anchored forms of the v-sis oncoprotein have been previously described which are oriented as type I transmembrane proteins and which efficiently induce autocrine transformation. Several examples of naturally occurring membrane-anchored growth factors have been identified, but all exhibit a type I orientation. In this work, we wished to construct and characterize membrane-anchored growt...

This article shows that the “risk premium” shock in Smets and Wouters (2007) can be interpreted as a structural shock to the demand for safe and liquid assets such as short-term US Treasury securities. Several implications of this interpretation are discussed. JEL Classification Numbers: E00, E1, E3, E4, E5, G1

The aim of this work was to prepare and evaluate the physicochemical properties film-forming polymeric solutions containing madecassoside asiaticoside. stability in vitro release were also investigated. Hypromellose E5 Eudragit® NE 30D used as agents. Glycerin a plasticizer. Ethanol is solvent for shortening film drying. best formulations composed 5 % hypromellose E5, glycerin, ethanol, Centell...

The goal of this investigation was to determine the effectiveness hydrophilic polymers in preparing a solid dispersion enhance solubility and dissolution poorly water-soluble drugs, such as curcumin. In order prepare dispersion, curcumin uniformly distributed polymeric matrix polyethylene glycol (PEG 6000), hydroxypropyl methyl cellulose (HPMC E5), polyvinyl pyrrolidine (PVP K30), bovine serum ...

Objective: The study aimed to develop fast-dissolving films (FDFs) of the immunosuppressant drug tacrolimus monohydrate for sublingual administration, employing central composite design (CCD), improve its bioavailability. Methods: Tacrolimus: β-cyclodextrin inclusion complexes prepared earlier were formulated into FDFs. CCD was used developing optimal film formulation with desired characteristi...