Abstract. Evolutionary algorithms (EA) are commonly used for solving optimization problems that can be stationary or dynamic. From an EA viewpoint, dynamic problems differ from stationary problems, mainly because in a changing environment, the EA needs to be able to track the optima through generations. Performance of an EA in dynamic environments is improved if the EA is modified to address th...

Development and maintenance of enterprise systems is becoming more difficult due to change drivers along multiple interconnected dimensions. It is advisable to model the enterprise first and analyze it for potential concerns. For modeling enterprises, ontologies have been considered apt and have been used in the past for the same, but application of ontologies for EA analysis based on concepts ...

Managing the enterprise architecture (EA) is a major challenge of every larger modern enterprise. Aligning business and IT in order to optimize their interaction is the main goal of EA management. The first step of an EA management approach typically is to analyze and document the as-is-situation. Subsequently, the second step has to be the management of the EA evolution in order to achieve the...

BACKGROUND Studies show that electroacupuncture (EA) has beneficial effects in patients with inflammatory diseases. This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia. DESIGN Four experiments were conducted on male Sprague-Dawley rats (n = 6-7/per group). Inflammation was induced ...

BACKGROUND Repeated electroacupuncture (EA) stimulation is known to stimulate the activity of the hypothalamus-pituitary-adrenal axis, and to enhance the circulation level of estrogen in the ovariectomized rats. To explore the source of the increased circulation estrogen, the extragonadal aromatization was detected. METHODS Female rats were divided into five groups: 1) intact (INT), 2) intact...

1 Motivation Today's enterprises find themselves confronted with a changing economic, regulatory, and technical environment that they are forced to adapt to (Ross et al. 2006, Wagter et al. 2005). Performing the necessary and beneficial adaptations is aggravated by the intricate and highly interwoven architecture of the overall enterprise. Therein, local changes to one enterprise artifact, e.g....

The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an a,~-unsaturated ketone, with glutathione and glutathione S-transferase PI-1 (GST PI-I) has been studied. When the glutathione conjugate of EA was incubated with a 5-fold molar excess of Nacetyi-L-cysteine or GST PI-I, a time-dependent transfer of EA to N-acetyI-L-cysteine or GST PI-1 was observed. With i...