BACKGROUND The neurodevelopmental risks associated with high total serum bilirubin levels in newborns are not well defined. METHODS We identified 140 infants with neonatal total serum bilirubin levels of at least 25 mg per deciliter (428 micromol per liter) and 419 randomly selected controls from a cohort of 106,627 term and near-term infants born from 1995 through 1998 in Kaiser Permanente h...

Abstract Introduction Rare cases of autoimmune hemolytic anemia (AHA) associated with using ciprofloxacin or hydrochlorothiazide (HCTZ) alone have been reported before. However, simultaneous use both drugs could lead to a severe clinical condition. This study presents the combination acute kidney injury (AKI) and AHA following HCTZ for three days. Case Description A 42‐year‐old Iranian woman pr...

We present an unusual case of hyperbilirubinemia with rapid early progression leading to bilirubin encephalopathy in a term neonate. Despite early recognition and intervention, the total serum bilirubin reached a maximum level of 39 mg/dL at 32 hours of life. Prior to an emergent exchange transfusion, the patient's diagnostic evaluation was significant for Coombs-negative microangiopathic hemol...

Advances in perinatal monitoring and early treatment for hyperbilirubinemia in high-risk patients have greatly reduced the incidence of kernicterus. Findings on MRI in patients with kernicterus are characteristic. The most characteristic pattern of neuropathological lesions in kernicterus is symmetric and highly selective involvement of the basal ganglia. In this study, we report the MRI findin...

Objective: Recently, the role of hemolysis in the pathophysiology of hyperbilirubinemia in glucose-6phosphate dehydrogenase  (G6PD)  deficient  neonates  has  been  questioned  and  decreased  bilirubin conjugation has been suggested. We conducted a study to evaluate the effect of hemolysis on these neonates at the 17-Shahrivar Children Hospital in Rasht.  Methods: In  this  cross-sectional  s...

Faldaprevir, an investigational agent for hepatitis C virus treatment, is well tolerated but associated with rapidly reversible, dose-dependent, clinically benign, unconjugated hyperbilirubinemia. Multidisciplinary preclinical and clinical studies were used to characterize mechanisms underlying this hyperbilirubinemia. In vitro, faldaprevir inhibited key processes involved in bilirubin clearanc...

BACKGROUND High bilirubin level is toxic to developing brain and auditory system but the current debate surrounds the toxicity of bilirubin in healthy term infants. METHODS Longitudinal observational study to find BERA abnormalities in term newborns with isolated hyperbilirubinemia of 20 mg/dL and more and to follow up babies at 3 months to find out about the reversibility in BERA abnormaliti...

Introduction: Neonatal hyperbilirubinemia is a widespread and significant clinical problem among neonates worldwide. Globally, every year about 1.1 million babies develop it the vast majority resides in developing countries like Ethiopia. It major cause of hospital neonatal intensive care unit admission readmissions during period. As far as our knowledge concerned there no such study con...

INTRODUCTION Hyperbilirubinemia is a common side effect of the antiretroviral agent atazanavir but is generally reversible upon discontinuation of treatment. We used therapeutic drug monitoring to investigate the occurrence of hyperbilirubinemia in a 49-year-old Hispanic man infected with HIV, following an overdose of ritonavir in ritonavir-boosted atazanavir therapy. CASE PRESENTATION A 49-y...