We report the results of a study carried out in 825 young football club members, all of whom underwent screening for hypertrophic cardiomyopathy using a 12-lead ECG. Echocardiographic assessment was performed in only those with positive ECG results, as defined by the European Society of Cardiology. Echocardiography proved necessary in 61 (7%) individuals with positive ECG findings, of whom 7 ha...

PURPOSE Recent reports have documented the appearance of Brugada-type ST elevation in cases of overdose of antiepileptic drugs (AEDs). However, little is known about changes on electrocardiographs (ECGs) during AED use at therapeutic doses. AEDs may cause Brugada-type ST elevation or J-wave-like intraventricular conduction delays through an ion channel-blocking effect. In the present study, we ...

1 of 2 DESCRIPTION Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an uncommon inherited cardiomyopathy caused by mutations of desmosomal protein genes responsible for cardiomyocyte electrical integrity and intercellular adhesion. ARVC is clinically characterised by: (1) electrical instability manifested by abnormalities of the resting ECG and ventricular arrhythmias. Sudden arrhythmi...

Cardiovascular complications associated with electroconvulsive therapy (ECT) for depression include dysrythmias, myocardial infarction, cardiac arrest, exaggerated hypertensive responses, and transient myocardial dysfunction.1-3 A variety of ECG changes have been demonstrated to occur in association with ECT and other central nervous system events. Although some studies have suggested that thes...

Any dysfunction in the calcium channels may be related to many signs or symptoms. On ECG the QT interval is the most sensitive electric phenomenon used to be altered by changes in the intracellular or extracellular calcium concentrations. We hypothesize that before the appearance of clinical signs of migraine, the impairments of ion channel function within genetically susceptible individuals mi...

BACKGROUND AND PURPOSE Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic arteriopathy caused by highly stereotyped mutations in NOTCH3. The clinical expression of CADASIL is confined to the central nervous system with characteristic recurrent subcortical infarcts and vascular dementia. However, cases have been reported ...

Methods and Results-—We studied 1462 participants in Bambu ı City, Brazil, with electrocardiogram (ECG) records classified by the Minnesota Code. Follow-up time was 10 years; the endpoint was mortality. Adjustment for potential confounding variables included age, gender, conventional risk factors, and B-type natriuretic peptide (BNP). The mean age was 69 years (60.9% women). The prevalence of C...

By simply adding a high concentration of calcium solution to the surface of the bullfrog heart, we reproduced electrocardiogram (ECG) abnormalities representing those observed in hypercalcemia, such as Osborn waves and shortening of the QT interval. The rise in extracellular calcium concentration may have activated the outward potassium currents during phase 3 of the action potential, and thus ...

OBJECTIVE To evaluate the prognostic significance of baseline electrocardiogram (ECG) abnormalities in a multiethnic cohort of patients with early systemic sclerosis (SSc) and to determine the serological, clinical, and echocardiogram correlates of ECG findings. METHODS SSc patients with disease duration of≤5 years were enrolled in the GENISOS (Genetics versus Environment in Scleroderma Outco...

BACKGROUND Q waves and negative T waves are common electrocardiographic (ECG) abnormalities in patients with Hypertrophic Cardiomyopathy (HCM). Several studies correlated ECG findings with presence and extent of fibrosis and hypertrophy; however, their significance remains incompletely clarified. Our study aimed to explain the mechanism behind Q and negative T waves by comparing their positions...