Tetraspanin CD151 is highly expressed in endothelial cells and regulates pathologic angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. Here we report that CD151 is required for maintaining endothelial capillary-like structures formed in vitro and the integrity of endothelial cell-cell and cell-matri...

the sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. the passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematopoieti...

background and objective: vascular endothelial growth factor (vegf) is a cytokine which is overexpressed in many malignant cancers including leukemia. vegf plays an important role in tumor invasion and metastasis. determination of the pattern of vegf expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

PURPOSE Loss of vascular barrier function has been observed shortly following vascular-targeting photodynamic therapy. However, the mechanism involved in this event is still not clear, and the therapeutic implications associated with this pathophysiologic change have not been fully explored. EXPERIMENTAL DESIGN The effect of vascular-targeting photodynamic therapy on vascular barrier function...

 Dental Pulp Stem Cells (DPSCs) can be found within the cell rich zone of dental pulp. These stem cells, under specific stimuli, differentiate into many cell types which have wide therapeutic applications.   The dental stem cells are derived from both deciduous and permanent teeth. The viable dental stem cells are very simple to collect, without any mortality and morbidity. Dental pulp stem c...

Background and Aims: Aim: Pathological vascular remodeling is the underlying cause of main cardiovascular diseases (CVD) including atherosclerosis abdominal aortic aneurysm (AAA). Diminished smooth muscle cell (VSMC) content a key mechanism atherosclerotic plaques AAA instability. We hypothesized that Galectin-1 (Gal-1) could exert protective effects in as previously demonstrated different chro...