Cutaneous immune-related adverse events (cirAEs) are the most prevalent complication to arise from immunotherapy. We determined spectrum, timing, clinical features, and outcomes of cirAEs by conducting an observational pharmacovigilance study (ClinicalTrials.gov, NCT04898751) employing Vigibase, WHO’s global database individual case safety reports. Using a Bayesian confidence propagation neural...

Lupi et al. present, on p. 80–81, an interesting case report of dyshidrosiform palmo-plantar pemphigoid. They describe a 20-year-old man who had had itchy vesicles on his palms and soles for 1 year. Histologically, a subepi-dermal vesicle was seen, and direct immunofluorescence showed continuous linear deposition of IgG and C 3 at the dermal-epidermal junction. An enzyme-linked immuno-sorbent a...

It is opportune to discuss occupational skin disorders since recently a 'Save your Skin' Campaign has been undertaken in the United Kingdom by the Employment Advisory Service of the Health and Safety Executive to increase the awareness of employers and employees of the need to prevent skin problems in industry.' This was justified because skin disorders caused by substances at work are the most...

BACKGROUND Recent investigations suggest an anti-inflammatory and antibacterial effect of hyperforin, which is a major constituent of Hypericum perforatum L. (Saint John's wort). OBJECTIVE In the present half-side comparison study we assessed the efficacy of a cream containing Hypericum: extract standardised to 1.5% hyperforin (verum) in comparison to the corresponding vehicle (placebo) for t...

Hyper-IgE syndrome (HIES), also called Job’s syndrome, [Online Mendelian Inheritance in Man (OMIM) #147060 and #243700] is a rare primary immunodeficiency disease, with an incidence lower than 1/10, not gender related, transmitted as an autosomal dominant or recessive trait with variable expressivity and of unknown etiology. HIES has been defined as a multisystem disease characterised by: 1) ex...

Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a combination preservative used in personal care and household products and is a common cause of allergic contact dermatitis (ACD). Recently, MI alone, without MCI, has been increasingly used in consumer products in attempts to minimize allergic reactions. Wet wipes are extensively tested and traditionally believed to be innocuous. M...

It is opportune to discuss occupational skin disorders since recently a 'Save your Skin' Campaign has been undertaken in the United Kingdom by the Employment Advisory Service of the Health and Safety Executive to increase the awareness of employers and employees of the need to prevent skin problems in industry.' This was justified because skin disorders caused by substances at work are the most...

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous morphology and intense itch. Heads Up was phase 3b, randomized, double-blind, double-dummy clinical trial comparing the efficacy safety of DUPI vs UPA in adults with moderate-to-severe AD over 24 weeks; OLE, all patients received 30 mg orally once daily for an additional 52 weeks. This analysis incremental...

Atopic dermatitis (AD) is a complex disease characterized by eczematous lesions over dry skin and local systemic oxidative stress. Indeed, patients with AD display increased concentrations of stress biomarkers in the urine, blood, saliva. Although source ROS uncertain, dysfunctional mitochondria might be involved excessive skin. In this study, we investigated epidermis using mouse model AD, i.e...