Genetic resistance and susceptibility to experimental Lyme arthritis have been linked with the production of interleukin-4 (IL-4) or gamma interferon (IFN-gamma), respectively. To determine the absolute requirement for these cytokines in disease outcome, we compared arthritis development in wild-type, IL-4-deficient (IL-4 degrees ), and IFN-gamma-deficient (IFN-gamma degrees ) mice. While susce...

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The distribution of receptors for Dolichos biflorus agglutinin (DBA) was studied by histochemical staining of paraffin sections with HRP- or FITC-DBA in mouse embryos at stages ranging from 4.5 to 12.5 days post coitum. Preimplantation blastocysts did not express DBA receptors. The receptors first appeared in primitive endoderm cells in 5-day embryos. In 5.5- to 7.5-day embryos, both the pariet...

Diamond-Blackfan anemia (DBA) is a rare congenital disease linked to mutations in the ribosomal protein genes rps19, rps24 and rps17. It belongs to the emerging class of ribosomal disorders. To understand the impact of DBA mutations on RPS19 function, we have solved the crystal structure of RPS19 from Pyrococcus abyssi. The protein forms a five alpha-helix bundle organized around a central amph...

IEEE 802.16 leaves important issues like uplink bandwidth allocation to vendors. This paper proposes an enhanced WiMAX DBA (Dynamic Bandwidth Allocation) algorithm using a reserved 2-tier Max-Min Fair Sharing Policy (2tMMFS_reserved-DBA) to improve the system performance than our previous 2tMMFS-DBA one. First, the algorithm reserves 10% of the total bandwidth for rtPS application before bandwi...

Indoor air quality (IAQ) is a growing concern, as people spend about 80–90 percent of their time indoors.It known that IAQ in office buildings influences people’s health. Employment agencies are one the most important institutions,where more than 1000 visit and hold interviews everyday. Measurements were made order to assess staff visitors building exposed to,and findings compared WHO ARSHAE st...

Vision loss in glaucoma is caused by progressive dysfunction of retinal ganglion cells (RGCs) and optic nerve atrophy. Here, we investigated the effectiveness of BDNF treatment to preserve vision in a glaucoma experimental model. As an established experimental model, we used the DBA/2J mouse, which develops chronic intraocular pressure (IOP) elevation that mimics primary open-angle glaucoma (PO...

In order to study a previously described genetic difference manifested in stem cell kinetics of specific mouse strains, effects of this putative gene, stk, were measured on growth and expansion of stem and progenitor cell populations ex vivo. Bone marrow cells from each of two inbred mouse strains, C57BL/6J and DBA/2J, were placed into separate bioreactor cultures perfused continuously with gro...

Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and differential effects on the auditory nerve-brain interface may have particular...