Treatment of ascites and solid tumors in mice (Sarcoma-1 and Ehrlich ascites carcinoma) with bovine enterovirus-1 resulted in regression of the tumors without any pathological effect on the animals. Death of mice with lymphatic-leukemia L4946 was delayed after such treatment. The oncolytic specificity of the virus does not appear to involve the production of interferon, but requires specific ad...

Since the original work of Fleming (1), many antibiotics have been isolated from culture filtrates of soil microorganisms. A few of the antibiotics have demonstrated anti-tumor effects in experimental animals (9, 25). Recently, Hata and his associates (8, 12), Sakai and Teranaka (11), and Teranaka (29) reported that mitomycin C, a new antibiotic isolated from Streptomyces caespitosus (4), has s...

The effects of Panfuran-S on the growth of Ehrlich ascites carcinoma cells have been studied. Marked cytoxic effects were observed in the experiments in which the tumor cells were incubated with the drug. In contrast to the effects on the tumor cells in vitro, treatment with the drug failed to inhibit tumor growth in Swiss ICR/ Ha mice receiving injection of the tumor cells whether it was admin...

The activities of citrate synthase and cytochrome c oxidase, mitochondrial marker enzymes, were evaluated in the liver of Ehrlich ascites carcinoma-bearing mice during the life span of the inoculated animals. After 10 days of tumour transplantation, when cell proliferation has ceased, a 30-40% decrease of these activities was detected in both liver and kidney. Simultaneously, an increase in the...

Methanol extract of C. indica (MECI) leaves showed direct cytotoxicity on Ehrlich ascites carcinoma (EAC) cell in a dose dependant manner and there was significant decrease in the tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile and biochemical estimations were significantly restored to normal levels in MECI treated as com...

As a part of a composite programme of rational drug design (RDD), we had synthesized some substituted benzenesulphonyl glutamines and evaluated their inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Modified Hansch-Fujita model...

In previous publications ( 1 ~ ) we have described the isolation from the microsomal fraction of Ehrlich ascites carcinoma (EAC) of two major membrane types, namely: (a) ER-type particles, arising primarily from the "smooth" endoplasmic reticulum, and (b) PM-type particles originating principally from the plasma membrane. We have also presented some details of the light-scattering properties of...

The binding proteins for Sarcophaga lectin and wheat germ agglutinin on the surface of Ehrlich ascites tumor cells were compared. Studies with antibody against the binding protein for Sarcophaga lectin showed that these two binding proteins are different. Since these two lectins are both active in the lectindependent macrophage-mediated cytotoxic reaction with Ehrlich ascites tumor cells as tar...

Addition of H(2)O(2) (0.5 mM) to Ehrlich ascites tumor cells under isotonic conditions results in a substantial (22 +/- 1%) reduction in cell volume within 25 min. The cell shrinkage is paralleled by net loss of K(+), which was significant within 8 min, whereas no concomitant increase in the K(+) or Cl(-) conductances could be observed. The H(2)O(2)-induced cell shrinkage was unaffected by the ...

Nickel(II) complexes of thiosemicarbazons were observed to be potent cytotoxic agents in human and rodent tissue cultured tumor cells. Each compound demonstrated a slightly different profile in the various histological types of tumors. The nickel complex of Appip demonstrated the most potent in vivo activity in the Ehrlich ascites carcinoma. This agent selectively inhibited L1210 DNA and purine...